Relationship Between E-selectin S128R Gene Polymorphism And Susceptibility Of Recurrent Aphthous Ulcer

Objective To explore the probable relationship between Recurrent Aphthous Ulcer(RAU)and E-selectin S128 R genetic polymorphism.Methods 109 patients diagnosed with RAU were gathered for this research.135 healthy people were choosed for this study.E-selectin S128 R locis were finded by restriction fragment length polymorphism-polymerase chain reaction(RFLP-PCR).Relative risk ratios were estimated by odds ratios(OR)and 95% confidence interval(95%CI).Results1.In the normal team,the genetype frequencies of E-selectin S128 R locis the same as the Hardy-Weinberg balance,and have a team’s representative.2.Important discrepancy were discovered in the genetype frequencies or allele frequencies of E-selectin S128 R sites between the RAU patients and controls(p<0.05).SR genotype(OR=4.902,95%CI=2.330-10.312),RR genotype(OR=6.740,95%CI=0.739-61.459),and R allele(OR=4.443,95%CI=2.309-8.546)at the E-selectin S128 R site exhibited high risks.Conclusion E-selectin S128 R is associated with RAU.E-selectin S128 R locis have a connectioned with the risk of RAU.The recurrent oral ulcer danger of the R allelomorph which with E-seletin S128 R locis is higher than those with the S allelomorph.