Comparative Analysis Of Clinical And Pathological Features Of Left And Right Colon Cancer

Objective To further analyze the characteristics and pathological characteristics of left-sided Colon Cancer(LCC)and right-sided Colon Cancer(RCC),so as to provide a clinical theoretical basis for clinical diagnosis,personalized treatment and prognosis of LCC and RCC.Methods Selected from January 2014 to August 2014 in NingXia hospital of gastrointestinal surgery to treat Colon Cancer radical were analysed retrospectively by reviewed the patients as the research object,by a Colon splenic flexure,the Colon Cancer,Colon Cancer,CC)divided into LCC and RCC,the clinical and pathological characteristics of patients with CC at different locations were retrospectively analyzed by statistical methods,so as to clarify the difference between RCC and LCC(P < 0.05 means statistically significant difference).Results1.Among the 97 patients included in the study,there were no statistically significant differences in gender,initial symptoms,tumor morphology,preoperative platelet(PLT),tumor TNM stage,tumor marker carbohydrate antigen 199(CA199),and immunohistochemical marker KI-67(P>0.05).2.Comparison of general conditions between LCC patients and RCC patients: average age of RCC patients(63.80± 11.40),average age of LCC patients(69.38 ±8.71),and younger age of RCC patients(T=2.69,P<0.05).3.Comparison of preoperative nutritional status indicators between LCC patients and RCC patients: the mean preoperative hemoglobin(Hb)level of RCC patients was 104.45±30.14g/L,while the mean preoperative hemoglobin level of LCC patients was 118.95 ±27.80g/L,showing a statistically significant difference(T=2.43,P<0.05).4.Comparison of pathological features and prognostic indicators between LCC patients and RCC patients: 4 patients(9.76%)with moderately differentiated RCC,31 patients(75.61%)with moderately differentiated RCC,and 6 patients(14.63%)with poorly differentiated RCC.There were 14 cases(25.00%)of patients with moderately differentiated LCC,40 cases(71.43%)of patients with moderately differentiated LCC,and 2 cases(3.57%)of patients with poorly differentiated LCC,with statistically significant differences(X2=6.529,P<0.05).The average CEA level of the patients with RCC was 23.08 43.13ng/ml,and that of the patients with LCC was 7.54 9.33ng/ml,with statistically significant difference(T=2.27,P<0.05).The total number of metastatic lymph nodes in RCC patients was 34,and the total number of metastatic lymph nodes in LCC patients was 104,showing a statistically signifycant difference(P<0.05),There were 22 patients(53.69%)with positive immunohistochemical markers for RCC,19(46.34%)with negative markers,17(30.36%)with positive markers for P53,and 39(69.64%)with negative markers for LCC,with statistically significant differences(X2=5.346,P<0.05).There were 26 patients(63.41%)with positive TOPO-II immunohistochemical markers for RCC,15(36.59%)with negative ones,43(76.79%)with positive TOPO-II markers for LCC,and 13(23.21%)with negative ones,with statistically significant differences(X2=5.346,P<0.05).ConclusionCompare with left half colonic cancer photograph,right half colonic cancer comes on age lower,preoperative hemoglobin level is lower,malign degree is higher,prognosis is poorer,the drug resistance that is right part changes cure medicaments is stronger,because this right half colonic cancer changes cure the adjustment that the program should notice morein the process of change cure.