Clinical Research On Kening Mixture For Treatment Of Cough Variant Asthma Of Wind Evil Concealed In Lung

Objective: To study the efficacy and safety of Kening Mixture in the treatment of cough variant asthma(wind-pathogenic pulmonary type),so as to provide guarantee for its further clinical application and promotion.Methods: A total of 88 CVA patients were randomly selected from 133 out-patients who met the inclusion requirements from Mianyang Hospital of Traditional Chinese Medicine,Yanting County Hospital of Traditional Chinese Medicine and Jiangyou Hospital of Traditional Chinese Medicine.They were randomly divided into group A(Kening Mixture Group)and group B(Suhuang Zhike Capsule Group)according to the ratio of 1:1,with 44 in each group.Group A was treated with Kening Mixture(20ml,tid)and group B was treated with Suhuang Zhike Capsule(3 capsules,tid)for two courses of treatment,one week for each course.Relevant information of patients was carefully recorded during the course of taking medicine.Visual Analogue Score(VAS),Cough Symptom Score Form and Major Symptoms Form were filled in.The data were analyzed by SPSS20.0 after the course of treatment.Result:1.Before treatment,baseline levels such as gender,age,and BMI in both groups of patients were statistically analyzed,the results showed no significant difference(P>0.05).2.Before treatment,there was no significant difference in indicators of VAS,cough Score,the main symptom score,the minor symptom score,P>0.05.3.There was a significant difference inscores of VAS,cough Score,the main symptom score,the minor symptom before and after treatment between the two groups(P<0.01).4.After treatment,there was no significant difference in cough symptom score between the two groups(P < 0.05),VAS,main symptoms,minor symptoms and total symptoms score(P > 0.05).5.There was no significant difference in VAS,cough frequency,main symptoms, secondary symptoms and total symptom score between the two groups after treatment,P > 0.05.6.After the treatment,the symptoms of cough relief at night between the two groups had statistical significance(P < 0.05),indicating that there were differences between A and B drugs in the relief of cough at night,but there was no significant difference between A and B drugs in the relief of cough at day(P > 0.05).7.After treatment,there was significant difference in the main symptoms between A and B(P < 0.05),but there was no significant difference in the treatment of shortness of breath and cough(P > 0.05),and there was no significant difference in the secondary symptoms between A and B(P > 0.05).8.Before treatment,there was no significant difference in the proportion of syndrome types of A and B drugs(P > 0.05),but after treatment,there was statistical significance in the treatment of different syndrome types of A and B drugs(P < 0.05),and there was statistical difference between liver-fire syndrome and wind-evil syndrome(P < 0.05).There was no statistical significance in the treatment of syndrome types of A and B drugs between groups(P > 0.05).9.No adverse reactions occurred in both groups during the treatment.Conclusion:Efficiency of the keningheji group was 86.36%,as well as efficiency of the Suhuangzhike Capsule group was 81.82% in the treatment of CVA.The two groups of results were treated with chi-square test,P>0.05,It suggests that the efficacy of keningheji is similar to Suhuangzhike Capsule in treatment of CVA,and no adverse reactions.It is worthy of clinical promotion because of its positive effects and high safety.