The Application Value Of Inflammatory Cytokines IL-1β And IL-6 In The Diagnosis Of Neurobrucellosis

Objective To determine the effect of inflammation on the cellular immune function of the central nervous system of neurobrucellosis patients,the detection and analysis of neurobrucellosis serum and cerebrospinal fluid IL-1β,IL-6 level is expected to provide ideas for the early diagnosis and treatment of neurobrucellosis and provide scientific basis for further exploration of the pathogenesis of neurobrucellosis.Method We selected patients who were in the outpatient and inpatient departments of the Affiliated hospital of Inner Mongolia medical university and Inner Mongolia center for disease control from January 2018 to December 2018.The experimental group included 37 patients with neurobrucellosis.The control group included 29 cases of non-neurobrucellosis,19 patients with viral encephalitis,and 23 normal controls.All patients underwent fasting venous blood sampling and lumbar puncture within 24 hours of admission.IL-1β and IL-6 levels were detected by MSD(Meso Scale Discovery).SPSS20.0 was used for statistical analysis.Results(1)Compared with the normal control group,serum IL-1β level was increased and serum IL-6 level was decreased in the non-neurobrucellosis group,with significant difference(P<0.05).(2)Compared with the normal control group,the levels of IL-1β and IL-6 in serum and cerebrospinal fluid of the neurobrucellosis group were significantly higher(P<0.05).(3)Serum and cerebrospinal fluid IL-6 levels in the neurobrucellosis group were significantly higher than those in the non-neurobrucellosis group(P<0.05).(4)Serum levels of IL-1β and IL-6 in the neurobrucellosis group were significantly higher than those in the viral encephalitis group(P<0.05).(5)In the neurobrucellosis group,cerebrospinal fluid IL-1β was positively correlated with IL-6 level(P<0.001,r=0.948).Conclusions(1)Inflammatory cytokine IL-6 is highly expressed specifically and highly sensitive to diagnosis in neurobrucellosis providing value for the early diagnosis of neurobrucellosis.(2)IL-1β and IL-6 levels were increased in the neurobrucellosis group.They play an important role in the development of neurobrucellosis.(3)Serum IL-1β and IL-6 levels are important for the antidiastole of neurobrucellosis and viral encephalitis.(4)IL-1β and IL-6 are involved in the pathogenesis of neurobrucellosis.Further exploration of its mechanism,if it can reduce the damage of excessive inflammatory response to the body,or find important targets of immune response,will contribute to the early clinical treatment of neurobrucellosis.