Pathogenesis Analysis Of Cardiovascular And Cerebrovascular Diseases Based On Carotid Atherosclerosis

Research purposes:(1)By analyzing the distribution of TCM atherosclerosis in different parts of the body to explore the commonalities and differences,in order to summarize the TCM pathogenesis of atherosclerotic cardiovascular and cerebrovascular diseases.(2)Tapped the correlation between TCM syndrome factors and clinical laboratory tests,plaque properties and other indicators.Research methods:Through retrospective clinical study,we collected 300 patients with carotid atherosclerosis in our hospital,including 100 patients with carotid atherosclerosis without cardiovascular and cerebrovascular disease,100 with carotid atherosclerosis and atherosclerotic cerebral infarction Cases,carotid atherosclerosis with coronary heart disease in 100 cases,the clinical symptoms and signs of patients were collected,according to "Syndromes Of Syndromes" in the measurement of symptoms,statistics of the points of the study of syndromes,generally 100 as the common threshold,Card element score reached or exceeded 70 diagnosis of the syndrome.By analyzing the distribution of TCM syndromes in different parts of atherosclerosis,we explore the pathogenesis of atherosclerotic cardiovascular disease.The indexes needed to be observed in each patient were recorded,including TG,CHO,HDL,LDL,Glu,HbA1 c,UA,Hcy,FIB-C,Crouse score and plaque properties Syndromes and clinical laboratory tests,the nature of plaque and other indicators of relevance.Research results:1?300 cases of atherosclerosis in different parts of the main syndromes of the main syndromes include liver,spleen,kidney,sputum,wet,stasis,heat,Qi,Yin.Among them,the syndromes of qi deficiency and dampness were not statistically different among the three disease groups(P >0.05).TheSyndromes of blood stasis and heat in coronary heart disease group and cerebral infarction group were significantly higher than those in carotid atherosclerosis group(P <0.01);syndrome factors liver,meridian,mind and moving wind in cerebral infarction group was significantly higher than carotid atherosclerosis and coronary heart disease(P <0.01).The levels of syndromes and lungs in coronary heart disease group were significantly higher than those in carotid atherosclerosis and cerebral infarction groups(P <0.01).The syndromes of hyperactivity and hyperactivity were significantly higher in carotid atherosclerosis and cerebral infarction groups Cardiopathy group(P<0.01),syndrome kidney in carotid atherosclerosis group was significantly higher than that of cerebral infarction group and coronary heart disease group(P <0.01),syndromes of qi stagnation in carotid atherosclerosis group and coronary heart disease group was significantly higher than cerebral infarction group(P <0.01).The above results were prompted at different parts of the atherosclerotic patients in the disease and disease syndrome factors.2?In the study of the correlation between plaque quality and clinical data,smoking was found to have significant statistical difference in the nature of plaque(P <0.01),of which the proportion of smoking in hypoechoic group was significantly higher than that in non hypoechoic group;Syndrome heat,kidney,qi deficiency in the nature of the plaque was statistically significant difference(P <0.01),which hypoechogenic group syndrome heat was significantly higher than non-hypoechoic group,rather than the hypoechogenic group syndrome hormone And the proportion of qi deficiency was significantly higher than the hypoechoic group.3?In the clinical data analysis of three disease groups,it was found that the group of cerebral infarction and coronary heart disease was significantly higher than that of carotid atherosclerosis on smoking and hypertension;the mean value of HCY in cerebral infarction group was significantly higher than that of the normal Heart disease and carotid atherosclerosis;Crouse score of coronary heart disease and cerebral infarction group was significantly higher than that of carotid atherosclerosis group;carotid atherosclerosis group was significantly higher than that of coronary heart disease and cerebral infarction group on CHO,HDL,LDL,HbA1c;Alcohol consumption in patients with coronary heart disease and carotid atherosclerosis was significantly higher.4 ? Correlation analysis of TCM syndrome factors and clinical test indicators showed that there was correlation between some indicators,of which the larger sputum was positively correlated with CHO and LDL,the correlation coefficient was 0.254;Hcy was positively correlated with liver and meridian,and the correlation coefficient was 0.201,0.276.In conclusion:1?The pathogenesis of atherosclerosis is related to syndrome liver,spleen,kidney,phlegm,humidity,blood stasis,heat,qi deficiency and Yin deficiency.Among them,the phlegm may be the basic pathogenesis,the blood stasis and heat are the important pathogenesis of atherosclerosis,which can easily lead to acute cardiovascular events.Dietary moderation or not to eat too much greasy food or old age or long illness or congenitally deficient,causes the loss of health delivery,renal gasification,water metabolic disorders,phlegmy wet endogenous,qi-blood operation impeded,the resistance in the arteries and veins,then lead to the formation of atherosclerosis.It is easy to get rid of blood stasis and heat,which can lead to acute cardiovascular events.2?Smoking might lead to plaque instability;syndrome heat might be a predictor of vulnerable plaque.3?Smoking and hypertension might accelerate the process of target organ damage of atherosclerosis;Hcy hyperlipidemia was a risk factor of cerebral infarction,which could be used as a predictor of clinical screening of high-risk patients with cerebral infarction,but not as a target of prevention and treatment;Carotid atherosclerosis was a risk factor for cerebral infarction,which coould be used as a predictor of coronary heart disease,and could predict the severity of coronary heart disease to a certain extent,the clinical should pay attention to early intervention of carotid atherosclerosis,the carotid ultrasound As a routine screening method for atherosclerotic cardiovascular and cerebrovascular diseases to identify people at high risk of cerebral infarction and coronary heart disease;avoiding long periods of heavy drinking might be a measure of reducing cerebral infarction,but drinking was not recommended as a reduction Coronary heart disease pathways.4?Syndrome sputum and CHO,LDL was positively correlated;blood Hcy levels and the syndrome of liver and meridians were positively correlated.