Analysis Of The Similarities And Differences In Clinical Features Of Human Cytomegalovirus Infection Between Preterm And Full-term Infants

Research objectives:To explore the similarities and differences in clinical features of human cytomegalovirus infection between preterm and full-term infants.Research methods:Retrospective analysis the data of 192 children diagnosed"cytomegalovirus infection"in the first hospital of Jilin University Neonatology Department from June 2015 to December 2017.According to gestational age,the 192 children were devided into two groups,including preterm infants group and term infants group.Clinical performance,complications,blood routine,blood biochemistry,hearing screening and other laboratory indicators of the two groups were compared.Research results:A total of 192 children were enrolled,including premature infants group106 cases and the full-term infants group 86 cases.In the premature infants group,65 cases were males,the gestational age ranged from 26~2/7/7 weeks to36~6/7/7 weeks and the mean was(31.91±2.98)weeks,the birth weight ranged from 0.84 kilograms to 3.31 kilograms and the mean was(1.71±0.62)kilograms,11(10.38%)cases were small size for gestational age,the mean Hb of 74 cases with anemia was(93.62±12.66)g/L,the median white blood cells count of 19 cases with leukopenia was(0.87±0.51)×10~9/L,the average of CK and CK-MB were(293.00±65.05)U/L and(114.94±60.15)U/L in 2cases with myocardial damage,the median ALT and AST were 95.3 U/L and176.6 U/L in 7 cases with abnormal liver function,9 cases(8.49%)had a positive result about plasma HCMV-IgM,22 cases(20.75%)were HCMV-pp65>2+.In the full-term infants group,42 cases were males,the gestational age ranged from 37 weeks to 42~6/7/7 weeks and the mean was(39.35±1.08)weeks,the birth weight ranged from 1.40 kilograms to 5.05kilograms and the mean was(3.13±0.61)kilograms,23(26.74%)cases were small for gestational age,the mean Hb of 21 cases with anemia was(94.38±13.19)g/L,the median white blood cells count of 7 cases with leukopenia was(1.15±1.03)×109/L,the average of CK and CK-MB were(347.40±148.41)U/L and(120.15±116.74)U/L in 2 cases with myocardial damage,the median ALT and AST were 126.4U/L and 127.5U/L in 17 cases with abnormal liver function,16 cases(18.60%)had a positive result about plasma HCMV-IgM,30 cases(34.88%)were HCMV-pp65>2+.There were statistically significant differences between the two groups in the incidence of small for gestational age,anemia,leukopenia,abnormal liver function,myocardial damage,positive HCMV-Ig M and HCMV-pp65>2+.There were no significant differences between the two groups in the incidence of intracranial hemorrhage,malformation,HCMV pneumonia,hearing impairment,congenitalhypothyroidism,hyperbilirubinemia,and thrombocytopenia(P>0.05).There were no significant differences between the two groups in the average Hb of children with anemia,the average number of WBC in children with leukocyte reduction,the average PLT of children with thrombocytopenia,the average of CK and CK-MB in the children with myocardial injury,the average blood TBIL of the children with hyperbilirubinemia,and the difference of ALT and AST in the children with abnormal liver function and liver function(P>0.05).Research conclusions:(1)Preterm infants are more susceptible to HCMV infection in this 192children.(2)Preterm infants than full-term infants were more prone to have anemia and leukocyte reduction after HCMV infection,but there was no difference in the level of hemoglobin and leukocyte reduction.The positive rate of HCMV-IgM in premature infants is lower than that in full-term infants.(3)The incidence of abnormal liver dysfunction and myocardial damage were higher in preterm infants than that in full-term infants infected HCMV,but there was no difference in the elevation level of CK,CK-MB,ALT and AST.The incidence of small size for gestational age in full-term infants was more than that in preterm infants.(4)There were on difference in the incidence of intracranial hemorrhage,developmental malformation,HCMV pneumonia,hearing impairment,congenital hypothyroidism,hyperbilirubinemia,and thrombocytopenia between preterm infants and full-term infants infected HCMV.