Clinical Study On Treating Functional Dyspepsia With Damp Stagnation And Spleen And Stomach Syndrome By The Second Anwei Decoction

Objective: To explore the clinical efficacy and mechanism of " the second anwei decoction " in the treatment of functional dyspepsia,dampness,spleen and stomach syndrome,so as to provide a theoretical basis for better guiding clinical application of " the second anwei decoction " recipe in the treatment of functional dyspepsia.Methods: From 2016 January to 2017 September in our hospital(affiliated Ruikang Hospital of Guangxi University of TCM)and functional dyspepsia with the western medicine diagnosis standard of TCM spleen and stomach department of outpatient and inpatient adverse stagnation spleen and stomach in 60 patients as the research object,according to the random number table method is divided into the treatment group(the second anwei decoction,and the control group(oral)Itopride Hydrochloride Dispersible Tablets),30 cases in each group.The treatment cycle of the two groups was 4 weeks.Two groups of clinically cured,effective,and effective patients were followed up for 3 months after the treatment cycle was sufficient.The changes of TCM symptom scores,plasma motilin and serum gastrin levels,the total clinical efficacy,adverse reactions and relapse rate in two groups before and after treatment were observed,so as to explore the effectiveness of " the second anwei decoction " in treating functional dyspepsia,dampness,spleen and stomach syndrome.Results:(1)A total of 60 patients were finally included in the statistical analysis of 57 cases.The age,sex and course distribution of the two groups were not statistically significant(P>0.05),which was comparable.(2)Overall clinical efficacy: after 4 weeks of treatment,the total effective rate of the treatment group was 89.66%,and the total effective rate of the control group was 67.79%.The total effective rate of the treatment group was higher than that of the control group.The difference was statistically significant(P<0.05),indicating that the curative effect of the treatment group was better than that of the control group.(3)Symptom improvement: before treatment,there was no statistical difference between the two groups before treatment(P>0.05),which was comparable.After 4 weeks of treatment,the total score of the two groups after treatment was significantly lower than that before treatment.The difference was statistically significant(P<0.01).After treatment,the total score of the treatment group was significantly lower than that of the control group after treatment.The difference was statistically significant(P<0.01),indicating that the improvement of symptoms in the treatment group was better than that in the control group.There was no statistical difference between the two groups before treatment.The difference was not statistically significant(P>0.05),and the difference was comparable.After treatment,the individual symptom score before treatment were significantly improved,and in addition to epigastric fullness,eating fullness two symptoms compared with the control group had no significant difference,the rest of the symptoms of treatment group improved significantly better than the control group(P<0.05);the control group after treatment except single symptom and treatment body weight tired limbs,nausea symptoms of two compared to the previous P value is less than 0.05,the remaining points and treatment of individual symptoms compared to before symptoms were significantly improved(P<0.01).(4)Motilin and gastrin levels: there was no statistically significant difference in plasma MTL and serum GAS levels between the two groups before treatment(P>0.05).The full course of treatment,treatment group and control group,the plasma MTL and serum GAS levels were higher than before treatment,and the treatment group,the serum GAS level of plasma MTL increased significantly(P<0.05),suggesting that the stomach No.two can effectively increase FD stagnation spleen stomach syndrome in patients with plasma MTL,serum GAS level,the may be related to the mechanism of the second anwei decoction.(5)Analysis of drug safety and recurrence rate: the two groups had no adverse drug reactions during the study.After 3 months of treatment,two groups of patients who were cured,effective and effective were followed up by telephone.The recurrence rate in the treatment group was 11.54%,and the recurrence rate in the control group was 57.89%.The recurrence rate in the treatment group was significantly lower than that in the control group(P< 0.01),indicating that the " the second anwei decoction " recipe is effective and safe in treating functional dyspepsia,dampness,spleen and stomach syndrome,and it can effectively reduce the recurrence rate of patients with functional dyspepsia,damp stagnation and spleen stomach syndrome.Conclusion: The second anwei decoction,can effectively improve the functional dyspepsia clinical symptoms of stagnation,spleen and stomach in patients with stable curative effect,high safety,low recurrence rate,worthy of clinical application;the second anwei decoction in the treatment of the mechanism of functional dyspepsia and dampness stagnation spleen stomach syndrome may be related to the increase of plasma motilin and related patients the level of serum gastrin.