Clinical Observation Of IgA Nephropathy With Deficiency Of Both Qi And Yin Treatment Shenqi Dihuang Decoction

Objective:To observe the effectiveness of Shenqidihuang Decoction on IgA nephropathy(IgA nephropathy IgAN)of Qi and Yin Deficiency type,to calendar the syndrome integral and urinary red blood cell count,24-hour urinary protein,serum immunoglobulin(IgA,IgG,IgM),to evaluate the treatment of Shenqidihuang Decoction on IgA nephropathy of Qi and Yin Deficiency type,and to explain the mechanisms.Methods:The patients diagnosed of IgAN were randomly divided into treatment group(30 cases)and control group(30 cases),treatment group were given daily Shengqidihuang Decoction,The control group were treated with Western medicine alone(dipyridamole),two groups were treated for 3 months.TCM syndrome score and urinary red blood cell count,24-hour urinary protein,serum immunoglobulin(IgG,IgM,IgA),renal function(Ccr,Scr,BUN)levels and other changes in laboratory parameters were observed and compared in two groups.Results:1 Comparative efficacy of diseases:in treatment group,the total efficiency was 86.6%,in the control group,the total efficiency was 63.3%.Tatal effective rate was significantly different 63.3%.Total effective rate was significantly different(u=2.24,P<0.05).The treatment group was better than the control group in the effect of disease.2 Comparison of syndromes:the rate of treatment group was 83.3%,in the control group the rate was 53.3%,total effective rate was significantly different(u=2.91,P<0.01).The treatment group was better than the control group in syndromes.3 Comparison of total score of clinical symptoms:After treatment,the total score of clinical symptoms between the two groups there was a significant difference(P:<0.01),treatment group was better than the control group.4 Comparison of individual symptom scores:After treatment,the individual symptom score between the two groups in shortness of breath,lassitude,feverish sensations in the chest,plams and soles,vulnerable to cold,there was a significant difference(P<0.01),the scores in dryness in the mouth and throat edema,there was a significant difference(P<0.05),treatment group was better than the control group.5 Urinary red blood cell count comparison:between the two groups after treatment,there was a significant difference(P<0.01),treatment group was better than the control group in the redument of urinary red blood cell count6 24-hour urine protein comparison:between the two groups after treatment,there was a significant difference(P<0.05),the treatment group reduced 24-hour urinary protein better than the control group.7 Serum immunoglobulin comparison:between the two groups after treatment,only a significant difference in IgA(P<0.05),treatment group reduced IgA better than the control group.Conclution:treatment group can effectively improve the clinical symptoms of patients with type Qi and Yin Deficiency,especially in shortness of breath,lassitude,feverish sensations in the chest,palms and soles,vulnerable to cold,dryness in the mouth and throat,edema,and it is significantly better than the control group.treatment groups is also effective in reducing urine and proteinuria,stable renal function and improve quality of life of patients,indicating that Shengqidihuang Decoction is an effective prescription for clinical treatment of IgA nephropathy of Qi and Yin Deficiency type and it may become a new,safe treatment...