Correlation Between TCM Syndromes Of Ovarian Reserve And Sex Hormones

ObjectiveThe study aims to explore the etiological factor of the diminished ovarian reserve(DOR),the relationship of age,TCM syndrome,menstruation pattem,self-rating depression scale(SDS)and sex hormone of DOR,so as to expand and refine the dialectical factor range,provide more ways for TCM differentiation of DOR,strengthen the compactness of traditional Chinese medicine and modern western medicine research.MethodsA cross-sectional study was performed in 84 DOR patients who were in accordance with the inclusive criteria and exclusion.The study was conducted by collecting their demographic and clinical data,detecting the basal follicle stimulating hormone(FSH)levels,basal estradiol(E2)levels,basal luteinizing hormonr(LH)levels,and the FSH/LH ratio.Datas were processed with SPSS20.0,with Wilcoxon test,Chi-square test,and spearmantest,and so on.Results1.DOR patients often stayed up late,and most of them owed bachelor degree or above,engage in mental labour,what’s more,they often had histories of artificial abortion,uterus or ovarian surgery,pelvic inflammatory disease,and histories of infection of mumps or herpes zoster virus.Patiants were divided into four age groups,20～24 age group,25～29 age group,30～34 age group,35～39 age group,the highest incidence of DOR was in the 35～39 age group.2.Hypomenorrhea(55.92%)was the main menstrual pattern of DOR.There was no significant difference in menstrual pattern distribution of different age groups(P=0.971>0.05).There was no significant difference in sex hormone of different menstraal pattern groups:(1)FSH(P=0.398>0.05),E2(P=0.054>0.05),LH(P=0.738>0.05),FSH/LH(P=0.601>0.05).(2)According to the trend,delayed menorrhea group had the highest FSH(15.288 mIU/mL)and the highest FSH/LH(4.570),preceded hypomenorrhea had the highest E2(81.13 pg/ml)and the highest LH(5.908 mIU/mL).3.Liver stagnation kidney deficiency syndrome(38.10%)was the main type of TCM syndrome.The others from high to low were liver and kidney Yin deficiency syndrome,spleen and kidney deficiency syndrome,kidney Yang deficiency syndrome,both Yin and Yang deficiency syndrome,kidney deficiency and blood stasis syndrome,phlegm-damp syndrome.There is no significant difference in type of TCM syndrome of different age groups(P=0.325>0.05).4.There existed a positive correlation between age and FSH(y=0.242*,P=0.027),and also a positive correlation between age and LH(γ=0.223*,P=0.042).There were differences among different age groups in FSH(P=0.002<0.05)and LH(P=0.006<0.05).There was no correlation between age and E2(P=0.554>0.05),and no correlation between age and FSH/LH(P=0.611>0.05).5.The distribution of FSH was significantly different in type of TCM syndromes(P=0.016<0.05),but there was no significant difference in E2(P=0.685>0.05),LH(P=0.418>0.05),and FSH/LH(P=0.078>0.05)distribution of type of TCM syndromes.In attention,there was no significant difference between FSH ≥10 and FSH/LH>2,FSH<10(P=0.174>0.05).6.There was no correlation between SDS and sex hormone(P>0,05),and there was no significant difference in sex hormone between depression and non-depression(P>0.05).7.There was no correlation between integration of TCM syndrome and sex hormone(P>0.05),however,there existed positive correlation between some syndromes and sex hormone:(1)Hypaphrodisia(γ=0.359**,P=0.001)and sleeping disorder(γ=0.288**,P=0.008)was positively correlated significantly with FSH,and oligo-vaginal discharge(γ=0.247*,P=0.023)was positively correlated with FSH.(2)Frequent micturition(γ=0.290**,P=0.007)was positively correlated significantly with E2.(3)Hypaphrodisia(γ=0.294**,P=0.007),sleeping disorder(γ=0.316**,P=0.003),and frequent micturition(γ=0.223**,P=0.042)were positively correlated significantly with LH.(4)Oligo-vaginal discharge(γ=0.48**,P=0.023),tidal fever with sweating(γ=0.303**,P=0.005)were positively correlated significantly with FSH/LH,and night sweating(y=0.216*,P=0.049)was positively correlated with FSH/LH.(5)Thirst was positively correlated with SDS(γ=0.222*,P=0.042),and hypaphrodisia(γ=0.288**,P=0.008),dizziness and tinnitus(γ=0.331**,P=0.002),and sleeping disorder(γ=0.328**,P=0.002)were positively correlated significantly with SDS.Conclusion1.Risk factors lead DOR:older age,staying up late,artificial abortion,uterus or ovarian surgery,pelvic inflammatory disease,and infection of mumps or herpes zoster virus,high education degree.2.Hypomenorrhea is the main menstrual pattern of DOR.There was no significant difference in sex hormone of different menstrual pattern groups.According to the trend,delayed menorrhea group had the highest FSH and the highest FSH/LH,preceded hypomenorrhea had the highest E2 and the highest LH.3.Liver stagnation kidney deficiency syndrome is the main type of TCM syndrome.Maybe it causes from the modern living habits.The distribution of FSH was significantly different in type of TCM syndromes,so FSH is more sensitive to TCM syndrome type.7.The sex hormone is positively correlated significantly with some TCM syndromes,it covers oligo-vaginal discharge,age,hypaphrodisia,sleeping disorder,tidal fever,night sweating,frequent micturition.