Study On The Correlation Between The Distribution Of Ovarian Reserve Deficiency Syndrome Factors And Sex Hormones And Blood Lipid

Objective:Based on the overall concept of traditional Chinese medicine and syndrome differentiation and treatment,this study takes patients with clinical diminished ovarian reserve(DOR)as the starting point,collects and analyzes the syndrome elements and laboratory related indicators of DOR patients,in order to improve the accuracy of clinical syndrome differentiation and treatment of DOR population,and provide a theoretical basis for clinical syndrome differentiation and treatment.And fully implement the application of TCM’ preventive treatment of disease’ in the target population,and provide new treatment ideas for the early evaluation of clinical diseases and the prevention and treatment of long-term complications.Methods:Through the form of questionnaire,DOR patients who met the inclusion criteria in Xiyuan Hospital of China Academy of Chinese Medical Sciences were collected.The basic data,four diagnostic information of traditional Chinese medicine,blood lipid and basic sex hormone levels were collected.Based on Excel and SPSS26.0 software,the statistical analysis was carried out to explore the TCM syndrome differentiation system and provide some reference for clinical treatment of DOR.Results:1 total of 134 valid cases were enrolled,including 100 cases(74.63%)in the 36-40 age group.The highest proportion of education was undergraduate(39.55%),mainly non-manual labor(91.79%),67.91%of patients fell asleep later than 23 o’clock,24.63%of patients were overweight or obese,14.18%of patients had central obesity,and menstrual changes or hormone changes were generally found in the past three years.2 In terms of the distribution of general syndromes in DOR patients,a total of 150 syndromes appeared.Severe pain(50.00%)was the main nature of pain,and aggravation after activity or fatigue(44.03%)was the main syndrome feature.Emotional changes were mainly manifested in irritability(37.31%),sighing(37.31%),and upset(37.31%).3 In terms of the distribution of syndromes in patients with DOR,116 patients(86.57%)had menstrual changes,including less menstrual flow(55.22%),delayed menstruation(16.42%),and amenorrhea(14.93%).At the same time,menstrual clips(55.22%)and dysmenorrhea(34.33%)were common.4 In the distribution of tongue and pulse syndromes in patients with DOR,tongue manifestations mainly include dark red tongue(46.27%),yellow tongue coating(46.27%),thin white tongue coating(38.06%),edge tooth marks(17.16%),pale and fat tongue(17.78%),etc.The pulse condition mainly includes pulse string(53.73%),pulse fine(53.73%),pulse slippery(46.27%)and so on.5 In terms of the distribution of disease location syndrome elements in DOR patients,there are 8 kinds of diagnostic criteria for syndrome elements.The frequency of occurrence from high to low is liver(50.75%),uterus(43.28%),kidney(30.60%),mind(5.2%),spleen(4.48%),bones(2.24%),stomach(1.49%),and meridians(0.75%).Among them,57 cases(62.64%)had concurrent disease location syndrome elements,with a total of 15 combinations.6 In terms of the distribution of disease syndrome elements in DOR patients,there were 11 kinds of diagnostic criteria for syndrome elements,and the frequency of occurrence from high to low was qi stagnation(78.13%),yin deficiency(65.63%),qi deficiency(48.96%),yang deficiency(47.92%),blood deficiency(32.29%),and blood stasis(28.13%).Among them,76 cases(79.17%)had concurrent disease syndrome elements,with a total of 40 combinations.7 SPSS26.0 software was used for cluster analysis of the main syndrome elements.It was concluded that the common syndromes of DOR patients were liver depression and qi stagnation syndrome,qi and blood deficiency syndrome,liver depression and yin deficiency syndrome,yang qi deficiency syndrome,liver and kidney yin and blood deficiency syndrome and blood stasis syndrome.8 Basic serum estradiol(E2)was negatively correlated with waist circumference and BMI.Basic serum follicle-stimulating hormone(FSH)was positively correlated with total cholesterol(TC)and low density lipoprotein cholesterin(LDL-C).AntiMullerian Hormone(AMH)was negatively correlated with LDL-C,and there was no linear correlation between Luteinizing Hormone(LH),E2 and blood lipids.9 There was a weak positive correlation between FSH level and kidney,blood deficiency and yin deficiency syndrome element scores,and there was a weak positive correlation between LH level and blood deficiency syndrome element scores.After further grouping of blood lipid levels,the difference in the distribution of main syndrome elements showed that the diagnostic rate of qi stagnation,qi deficiency and yin deficiency syndrome elements in the TC marginal elevation group was higher than that in the TC level.Conclusions:1 Liver,uterus and kidney are the main pathological elements in DOR patients;actual elements account for a large proportion of qi stagnation,followed by blood stasis;deficient elements are led by yin deficiency,followed by qi deficiency,yang deficiency and blood deficiency,and many elements are combined;clinical treatment pays attention to tonifying the kidney and draining the liver,and pays attention to qi,blood,yin and yang,providing a basis for clinical standardization of diagnosis and treatment.2 There is a positive correlation between FSH level and kidney,blood deficiency,and yin deficiency evidence points,and the diagnosis rate of qi stagnation,qi deficiency,and yin deficiency evidence elements is high in people with higher TC level,which provides clinical basis and theoretical foundation for combined Chinese and Western medicine treatment.3 There is a correlation between sex hormone levels and blood lipid levels.With the decrease of ovarian reserve function,TC and LDL-C levels increase.Therefore,early treatment of patients with ovarian reserve dysfunction can help reduce their long-term cardiovascular risk and provide a theoretical basis for clinical ’ preventive treatment of disease’.