Clinical Observation On The Treatment Of Benign Paroxysmal Positional Vertigo With FoShouDingXuanTang

Objective:In order to provide theoretical support and practical basis for clinical rational drug use,the clinical efficacy and safety of FoShouDingXuanTang in the treatment of benign paroxysmal positional vertigo are evaluated by clinical observation of FoShouDingXuanTang.Methods: 80 patients who were diagnosed benign paroxysmal positional vertigo in department of neurology,Gansu provincial hospital of Traditional Chinese Medicine from January to November,2016 and conform to the inclusion criteria of this study were randomly assigned to 2 groups: the treatment group and the control group.Each group contains 40 patients.The treatment group was treated with Fo ShouDingXuanTang and canalith repositioning procedure and the control group was treated with only canalith repositioning procedure.Two groups were treated with the established methods for clinical observation and treatment.Routine analysis of blood and urine,liver and kidney function tests and adverse reactions during medication were chosen as evaluation indexes of safety.Traditional Chinese Medicine syndrome score,dizziness disorder scale(DHI)symptom score,TCD and the number of vertigo relapse during follow-up treatment were used as evaluation indexes of curative effect.The efficacy and safety of the treatment for two groups were evaluated based on the indexes mentioned above.Results: The control group contained 40 cases of which 2 were lost.The final analysis was based on the results of 40 cases of treatment group and 38 cases of control group.(1)Clinical efficacy of Traditional Chinese Medicine syndrome score of two groups: the total effective rate of treatment group and control group were 95% and 78.95%,respectively.For the clinical efficacy of Traditional Chinese Medicine syndrome,the treatment was effective for both groups and the result of treatment group was superior to the control group(P<0.05).(2)For dizziness disorder scale(DHI)symptom score,the treatment was effective for both groups and the result of treatment group was superior to the control group(P<0.05).(3)TCD comparison of two groups: VA and BA peak of blood flow was significantly improved(P<0.05)for treatment group while there was no significant difference(P>0.05)for control group after treatment.The result of treatment group was superior to the control group(P<0.05).(4)Evaluation of efficacy stability: the follow-up examination on the 28 th and 60 th day of treatment for both groups were carried out.There were 5 and 14 relapse cases in the treatment group and control group on the 28 th day,the relapse rate of the treatment group and control group were 12.5% and 36.84%,respectively.The difference between the two groups was statistically significant(P<0.05).And there were 9 and 20 relapse cases in the treatment group and control group on the 60 th day,the relapse rate of the treatment group and control group were 22.5% and 52.63%,respectively.The difference between the two groups was statistically significant(P<0.05).(5)Evaluation of safety: there was no significant difference for both groups after treatment in routine analysis of blood and urine,liver and kidney function tests and no obvious adverse reactions occurred during medication,which proves the safety of FoShouDingXuanTang.Conclusion: The treatment of benign paroxysmal positional vertigo with FoShouDingXuanTang is effective,has no obvious side effects and can reduce the relapse rate.Besides,patients can benefit from FoShouDingXuanTang to reduce the degree,intensity and frequency of vertigo.It is a method that is worth promoting for application.