Efficacy And Safety Of Noninvasive Positive Pressure Ventilation In The Treatment Of Acute Respiratory Failure Due To Different Etiologies

ObjectiveTo evaluate the efficacy and safety of noninvasive positive pressure ventilation(NPPV)due to different etiologies.MethodsSelected acute respiratory failure(ARF)patients from January 2010 to December2015.The patients were further classified into two groups based on the etiology of ARF as COPD–ARF and ARF due to other causes.Data were gathered on sex,age,APACHE II score,vital sign,arterial blood gases(pH,partial pressure of oxygen in the arterial blood [PaO2],partial pressure of carbon dioxide in arterial blood [PaCO2])at baseline,one and two-four hours.Re-intubation rates,mortality rates and RICU stay were compared.ResultsDuring the year of study,123 patients(69 were male and 54 were female with a mean age of(71.0±11.6)years were enrolled,COPD-ARF group had 79 patients and ARF due to other causes 44 patients.COPD-ARF group had significantly(P<0.05 or P<0.01)lower endotracheal intubation rate(5.1%),hospital mortality(5.1%)as compared with ARF due to other causes(15.9% and 27.3% respectively).COPD-ARF group had higher success rate(89.9%)than ARF due to other causes(72.7%).There was no difference in the RICU stay(15d vs.16 d,P>0.05).The heart rate,respiratory rate and arterial blood gas analysis values(pH,PaCO2 and PaO2)were significantly improved as compared with baseline values after 1h?2-4h of NPPV therapy,and there were no significant between-groups differences either at baseline,1h or 2-4 h oftreatment.ConclusionsOur study indicates that NPPV is more effective in preventing endotracheal intubation in ARF due to COPD than other causes.It can also reduce the incidence of complications.