| Backgroud Esophageal cancer is a common clinical malignant tumors,which occurred in the epithelial tissue of the esophagus. The incidence is influenced by genetic eating habits, living environment and other factors. In recent years, more and more patients got esophageal cancer. China’s accounted for most of the esophageal cancer patients in the world, and there is a significant regional difference. The treatment of esophageal cancer has undergone surgery, chemotherapy, and then comprehensive treatment. Early esophageal cancer can be treated by surgery; middle-late tumor has the occurrence of metastasis to the cancer cells, but also can be treated by surgery, or preoperative nonadjacent chemotherapy.High dose of chemotherapy drugs can lead to killing cancer cells and shrink the tumor volume.Now western medicine has achieved ideal clinical results in improving the resection rate, reduce complications and mortality. However, radiation and chemotherapy usually cause bone marrow inhibition, decreased immunity, etc., the seriousness of side effects influence the patient’s quality of life, and even reduce patient surial.Traditional Chinese medicine with radiotherapy, chemotherapy and surgery can significantly reduce the adverse effects of esophageal cancer, enhance immunity, strengthen anti-cancer effect, improve the patient’s quality of life and survival.Application of combined treatment of traditional Chinese medicine and surgery and radiation and chemotherapy of esophageal cancer is very necessary. However,,election party of TCM requires a higher level of TCM physicians, unified decoction brewed method result in a greatly reduced effectiveness of the actual medicine.These are significant factors that affect the current development of Chinese medicine. It is the key which causes the stagnant of Chinese medicine in treating cancer. Therefore, looking for a kind of convenient and quick drug for clinical use to improve patients with cachexia, reduce the radiation and chemotherapy adverse reaction, and decrease the postoperative recurrence rate, is becoming a hot spot of current research.Objective Compound Shougong powder is a characteristic preparation of Anhui Province Hospital of traditional Chinese medicine, it was applied for more than ten years and had good effect of application in our hospital. According to the preliminary study of literature [], compound Shougong powder can inhibit tumor growth, improve the immune function after radiotherapy in patients with esophageal cancer and improve their quality of life.Therefore, this topic retrospective study of cases of esophageal cancer nearly 10 years in Anhui Province Hospital of Oncology in hospital,in order to find the advantages of compound Shougong Powder involved in the treatment areas, and explore the optimal stage treatment modality of esophageal cancer with compound Shougong Powder.Methods Collect all esophageal cancer patients which hospitalized in the First Affiliated Hospital of Anhui University of TCM during the Section 2005.1.1-2014.12.31, and fill out the "esophagus retrospective study case report forms".Record basic information, incidence and treatment,taking the compound Shougong powder, recurrence and metastasis, KPS score change, pain and control situation and overall survival, follow-up to 2015.12.31.Result 1, Collecting a total of 488 cases of esophageal cancer patients, included in the final analysis of 234 cases.234 patients, admission time mainly concentrated in 2011-2014, accounting for 71.4 percent of all cases; the proportion of male to female is 3.44:1; male patients with an average age of 64.08 + 9.798 years; female patients with an average age of 66.6 + 9.269 years old. There were no statistically significant differences in age of onset between male and female. Age between 60 and 70 is the age of high incidence of onset, patients younger than 40 years old is very rare. 2,The lesions of 488 cases: Thoracic most, followed by gastroesophageal junction, cervical happened;histological types:squamous cell carcinoma most, followed by adenocarcinoma,minimum of other types; clinical stage:Mid most,followed by advanced cancer, early at least. 3,The general situation of the treatment group compared with control group : gender(P=0.184), age(P=0.358),Clinical stage(P=0.447), pathological stage(P=0.568), treatment(P=0.662), TCM syndrome(P=0.374). There were no significant differences. 4,Treatment results:Treatment results:(1) Treatment group and control group survival Log-rank test P = 0.219,there’s no significant difference in overall survival, but when the survival time > 40 months. The survival rate of the treatment group was higher than that of the control group.The survival of treatment group was 52.026 + 3.228,95% confidence interval [46,58]. The survival of control group was 43.227 + 3.182,95% confidence interval [45,54].The median survival time of the treatment group was 46, The median survival time of the control group was 37. The average survival time and median survival of the treatment group were higher than the control group.(2) progression free survival: For early esophageal cancer patients, the treatment group progression free survival period were higher than that of the control group(P = 0.032), and for patients with advanced two groups had no significant difference in progression free survival(PFS).(3) the treatment group and the control group had no significant difference at 1 year, 3 years survival rate(P=0.401, P = 0.184), 5 years survival rate in treatment group was significantly higher than that of the control group(P = 0.027).(4) in the treatment of solid tumors between the treatment group and the control group: markedly effective rate was not significantly different, stable rate of the treatment group was higher than that of the control group and the progression rate in the treatment group was lower than that in control group.(5) quality of life in patients with advanced: treatment time of less than 3 Month, KPS score had no significant difference, with the extension of treatment time, KPS score in treatment group gradually higher than the control group. The oxycodone usage of the treatment group and the control group had no significant difference. 5,Survival analysis: single factor analysis showed that the five factors,clinical stage, pathological types, treatment, TCM syndrome type, KPS score were significantly correlated with prognosis; multivariate analysis showed that, clinical stage and KPS score were closely related with the prognosis of esophageal cancer.Conclusion 1,Conclusion: 1the incidence of male patients with esophageal cancer was significantly higher than women,patients of 60~70 years old who had symptoms of dysphagia should be highly suspected of esophageal cancer; 2,Compound Shougong powder can improve the mean survival time and prolong the median survival time of the patients with esophageal cancer, and beneficial in long-term survival of patients with esophageal cancer; compound Shougong powder can reduce the recurrence rate of early esophageal cancer; compound Shougong powder can improve 5-year survival rate of esophageal cancer patients; compound Shougong powder can slow down the progression of esophageal carcinoma; compound Shougong powder can improve the KPS scores of patients with esophageal cancer,and improve the quality of life of the patients. 3,the prognosis of esophageal cancer is closely related to the tumor staging and KPS score, so early detection, early treatment can significantly improve the prognosis of patients with esophageal cancer. |
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