Effect Of Compound Shougong Powder Combined With Chemotherapy On The Immune Function Of Advanced NSCLC And Its Clinical Effect

ObjectiveTo investigate the clinical observation of compound shougong powder on the basis of chemotherapy on the immune function,short-term efficacy,serum CEA level and KPS score of advanced NSCLC.It is expected to provide clinical reference for the prevention and treatment of malignant tumors by traditional Chinese medicine.MethodsThe clinical study of patients from January 2018 to August 2019 housed in anhui university of TCM oncology,respiratory and clear diagnosis of 62 patients with locally advanced NSCLC,31 cases were randomly divided into observation group and control group in 31 cases,in the process of research meet the 8 cases of excluding standard,finally in accordance with the requirements for clinical trials of observation group 29cases,control group 25 cases.Both groups were given TP regimen(4 courses)based on cisplatin 20mg/m2,intravenous infusion,day 1-3;Paclitaxel 175mg/m2 was given intravenously for 3 hours.Repeat every 3 weeks for a total of 4 sessions.During chemotherapy with routine allergy prevention,acid stomach protection,liver protection and other treatments.In the observation group,compound shou gong powder was added to the basic plan(5g hot water was taken once a day in the morning and evening,and was routinely taken during chemotherapy and between treatment courses).Before and after treatment,immune cells,IL-2,IL-10,recent disease control rate,KPS score,serum CEA and related adverse reactions were evaluated in the two groups.Results1.Effect on immune function:after treatment,the values of CD3~+T,CD4~+T,CD4~+T/CD8~+T and NK cells in the control group all decreased compared with the p revious ones.The comparison between CD4~+T and pre-treatment was P=0.005<0.01,and the decrease was statistically significant;After treatment,the values of C D3~+T,CD4~+T,CD4~+T/CD8~+T and NK cells in the observation group all increased compared with the previous ones,and the CD3~+T was P=0.032<0.05 compared with that before treatment,with statistically significant difference.CD4~+T was c ompared with that before treatment,P=0.004<0.01,and the difference was statisti cally significant.After treatment,the differences of CD3~+T,CD4~+T/CD8~+T and C D4~+T between the two groups were statistically significant(P<0.05).After treatm ent,IL-2 level in the control group decreased compared with that before,and P=0.022<0.05 for intra-group comparison,with statistically significant difference.T he level of IL-2 in the observation group was increased compared with that befo re,and the difference was statistically significant for intra-group comparison(P=0.038<0.05),and the difference was statistically significant for inter-group comparis on(P=0.044<0.05).There was no significant difference in the P values of>0.05between the two il-10 groups or between the two groups after treatment.This in dicates that fufang shougong powder can improve the level of CD3~+T,CD4~+T ce lls and serum IL-2 to a certain extent and improve the effect of chemotherapy o n immune function.2.Effect on short-term efficacy:comparison of short-term efficacy between the two groups after treatment P=0.125>0.05,no statistical difference.However,the recent disease control rate in the observation group was higher than that in the control group.3.Effect on serum CEA:P<0.05 was compared between the control group after 2 and3 cycles of treatment and the group before treatment,and the decrease was statistically significant.All P values in the observation group were<0.05 before and after each cycle of treatment,and the decrease was statistically significant.There was no statistically significant difference in P,>0.05 between the two groups.4.Influence on quality of life:The P values of the control group after the second,third and fourth cycles of treatment were all less than 0.05 compared with the group before treatment,and the decrease was statistically significant.The P values of the observation group after each cycle of treatment and before treatment were all greater than 0.05,and the change in KPS score was not statistically significant.After treatment,the difference of KPS rating between the two groups was statistically significant(P=0.030<0.05).5.Adverse events:the frequency of adverse events was similar between the two groups(P>0.05),and the difference was not statistically significant.Conclusion1.compound shougong powder can improve the effect of chemotherapy on immune function.It can mainly increase the levels of CD3~+T,CD4~+T cells and serum IL-2.2.There was no statistical difference in the short-term efficacy between the two groups after treatment,but the disease control rate in the observation group was higher than that in the control group.The results showed that compound shougong powder combined with chemotherapy could slightly improve the efficacy of advanced lung cancer to a certain extent,and long-term use could continue to play a stabilizing role.3.After treatment,the overall serum CEA level of both groups showed a downward trend compared with that before,but there was no statistical significance between the two groups.The effect of compound Shougong powder combined with chemotherapy on serum CEA was not better than that of the control group.4.Compound shougong powder can stabilize KPS score and reduce the impact of chemotherapy on quality of life.5.Compound shougong powder failed to increase the occurrence of adverse reactions.