Clinical Curative Effect Of The Decoction Of Clearing Away The Lung-heat And Hyposensitizing On Allergic Rhinitis With Pattern Of Heat Stagnation In Lung Channel

Allergic rhinitis is a common and frequently occurring disease of otolaryngology. In recent years, along with the increase of worldwide allergic diseases, an upward trend exists in the incidence of allergic rhinitis in the general population. It’s a kind of allergic inflammatory disease of nasal mucosa caused by atopic individuals exposing to an allergen, stirring up to release of media (mainly histamine) mediated by IgE, and a variety of immune cells and cytokines involved in the course. Its symptoms appear at any age, the most common in adolescence or young adults[1]. At present, western medicine treatment of the disease has made great progress, but drug side effects, operation risk or expensive fare, relapse and many other shortcomings are still ubiquitous. In recent years, the Chinese medicine treatment system of the disease mature increasingly, and both stresses general concept and deals with the clinical manifestation and essence as well. Also it has advantages on improving the long-term curative effect. This study aims at completing Chinese medicine treatment system of AR, through the observation and evaluation of clinical efficacy of a clinical commonly used formula towards AR with pattern of heat stagnation in Lung Channel.Objection:This topic is designed to observe and evaluate the clinical curative effect of the decoction of clearing away the lung-heat and hyposensitizing on allergic rhinitis with pattern of heat stagnation in Lung Channel with western medicine as control group, aiming at providing evidence for clinical medication of Chinese medicine towards AR.Method:Select60cases from outpatients, meeting the criteria, and divide them into two groups. Oral administration of decoction of clearing away the lung-heat and hyposensitizing twice per day as the treatment group, while levocetirizine hydrochloride tablets at bedtime as the control group. Additionally, children weighed below30kg from the treatment group take half the adult dosage. Children aged at4-17and weighed below30kg from the control group take2.5mg levocetirizine hydrochloride and the others take5mg at bedtime, which all are marked as mild ones. Towards moderate and severe ones, budesonide nasal spray should be auxiliary. Spray once in each nostril, morning and evening each. Besides, children aged at4-6used fluticasone propionate nasal spray instead of budesonide, and spray once in each nostril in the morning. Treatment for4weeks, and record the symptoms and signs integral at the7th,14th,21th and28th day respectively after the medication, evaluating the curative effect as well.Results:1. Before and after treatment there were significant differences in the primary symptom and signs integral in the treatment group (P<0.01), indicating effective treatment of the decoction towards AR with pattern of heat stagnation in Lung Channel.2. After one or two weeks of treatment, the control group does better, while after four weeks of treatment both groups show therapeutic equivalence. And the decoction group does better in improving rhinocnesmus and rhinorrhoea (P<0.05).3. After4weeks of treatment, there were remarkable curative effect in5cases (16.67%), effective in22cases (66.67%), ineffective in3cases (10%) and a total effective rate of90.00%in the treatment group. The control group had a total effective rate of86.67%with6of remarkable curative effect (20.00%),20of effect (66.67%) and4of no effect (13.33%). It indicated that obvious differences absent between the two groups (P>0.05).4. The children group had a similar distribution with the adult group, as well as the curative effect (P>0.05), and the total effective rate also, meaning little relationship with age difference.5. Comparison of the relapse between the two groups showed an obvious difference (P<0.05)3months after treatment, with the treatment group preceding, the same as6months later (P<0.05). That is to say, the decoction does good in reducing relapse rate, indicating fine prospective efficacy.Conclusion:Decoction of clearing away the lung-heat and hyposensitizing is effective towards AR with pattern of heat stagnation in Lung Channel, and does better in improving rhinocnesmus and rhinorrhoea than western medicine, as well as improving subordinate symptoms, and shows fine prostecdtive efficacy.