The Changes And Clinical Significance Of Peripheral Blood Platelet-To-Lymphocyte Ratio And Neutrophil-To-Lympphocyte Ratio In Patients With Kawasaki Disease

Objective: Through retrospective analysis of the patients with Kawasaki Disease, to know the diagnostic value of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in Kawasaki Disease, and then to provide a basis for the diagnosis and prognosis of Kawasaki Disease.Methods: The study comprised 234 subjects who were diagnosed Kawasaki Disease, and discharged from the cardiology department of the Children’s hospital of Chongqing Medical University from September 01, 2014 to June 01, 2015. The peripheral blood test results before and two days after intravenous immunoglobin therapy, C-reactive protein, erythrocyte sedimentation rate, procalcitonin, and cardiac color Doppler ultrasound examination results during hospitalization of these patients were obtained. The study also included the peripheral blood test results of 200 healthy subjects of similar age and sex as control group.Results:(1) In the KD patients group, the PLR and NLR values were significantly higher compared to control group(P=0.000);(2) Male、neutrophil、percentage of neutrophil and the NLR value of the complete Kawasaki Disease group were significantly increased, lymphocyte and percentage of lymphocyte were significantly decreased;(3) Decrease of hematocrit、platelet and the PLR value, increase of the white blood cell、neutrophil、percentage of neutrophil、the NLR value and procalcitonin are related to intravenous immunoglobin resistant;(4) Intravenous immunoglobin resistant may be related to coronary artery aneurysm; <6 months、male were more likely to have coronary artery lesions; before and after intravenous immunoglobin therapy, the differences of PLR、NLR values between NCAL-KD and CAL-KD group, NCAL-KD and CAA-KD group had no statistical significance(P>0.05), and the hematocrit and hemoglobin decreased, platelet increased may be related to coronary artery lesions and coronary artery aneurysm occurrence.Conclusion:(1) The PLR and NLR values had auxiliary diagnostic value for Kawasaki Disease;(2) The NLR value of complete Kawasaki Disease group was significantly higher;(3) Decreased of the PLR value and increased of the NLR value were related to intravenous immunoglobin resistant;(4) The PLR and NLR values had no significantly relationship with coronary artery lesions and coronary artery aneurysm occurrence.