| Chemotherapy is an effective method for gastric cancer treatment, but chemoresistance has become an important factor affecting the efficacy. Reinforcing qi strengthening spleen prescription is an experienced efficacious prescription for gastric cancer treatment by Professor Liu Shenlin. The prescription has been proved by clinical efficacy and meanwhile in combination with chemotherapeutics can increase effect and decrease toxicity. To further evaluate the clinical effect in chemotherapy, this study will follow GCP and adopt double-blind, basic treatment with Chinese herb and placebo controlled method to evaluate the difference efficacy of conventional chemotherapy to the efficacy with Chinese herb, and for clinic applications provide objective evidence.Theoretical inductive studyFirstly, from a theoretical perspective to overviewed the etiology, incidence and diagnosis of gastric cancer. Gastric cancer belongs to Chinese Medicine "epigastric pain, nausea, dysphagia, mass in the upper abdomen, vomiting, bloating, abdominal mass, accumulation". Chinese medicine generally believe that the attack of improper diet, emotional disorders, overstrain internal injuries, exogenous poison and other internal and external factors. Spleen deficiency and yunhua shisi lead to indigestion, phlegm, qi stagnation, and blood stasis, heat toxin are its main pathological properties. Chinese medicine treatment often starts from the diagnosis, basic prescription adjustment, integrative medicine, acupuncture and other methods. overview of the clinical situation, have made significant progress. Modern medicine believe that gastric cancer is closely related to HP infection, EB virus infection, improper eating habits and behavior, genetic factors, environment and race and host their own factors. According to these circumstances doctors often Use conventional methods of surgery, chemotherapy, radiotherapy, while with advances in technology, adopt targeted therapy and Immuno-Biological Cancer Therapy to make an affirmative clinical efficacy and significant progress. But meanwhile bone marrow suppression, gastrointestinal side effect, damages the immune system and other toxic and adverse effects are obvious. This paper by summarize literature shows that coordinate with Chinese medicine could improve patient survival quality and enhance anti-tumor effect, reduction in toxicity and prevention of recurrence. reinforcing qi strengthening spleen prescription has been clinical application for many years, part of studies have shown that conjunction with chemotherapy could increasing effect and decreasing toxicity, reduce side effects of chemotherapy and improve patient survival quality. Therefore it is necessary to scientific evaluate the curative effect of reinforcing qi strengthening spleen prescriptionClinical StudyObjective:follow GCP specification to have on clinical design. Adopt double-blind, parallel-group method of basic treatment with Chinese herb, variance evaluation of conventional chemotherapy and reinforcing qi strengthening spleen prescription. Methods:to collect 68 Patients with gastric cancer who met the inclusion criteria and divided them into experimental group (DC program+reinforcing qi strengthening spleen prescription Mianjian granule) and the control group (DC program+reinforcing qi strengthening spleen prescription simulation granule), observed and compared their vital signs, survival quality, Chinese medicine symptoms and physical state changes after 2 courses (56 days) of treatment. Results: The experimental groups in of gastric cancer patients were better in performance status, survival quality, and Chinese medicine symptoms than the control group. Particularly has a significant advantage in terms of improvement of symptoms and signs. Conclusions: reinforcing qi strengthening spleen prescription can significantly improve the survival quality of gastric cancer patients. |
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