| Vitiligo is an acquired and idiopathic dermatosis with localized or generalized skin hypopigmentation.The global prevalence rate is about 0.06%-2.28%, there are about 50% patients with onset before 20 years of age,25% of the patients in the 8 years before onset. As a treatment of vitiligo,TCM therapy has made great progress in therapy, external therapy and acupuncture.Because of the special physiological and pathological characters, the TCM syndromes and treatments of children are different from adults.However, the absence of children vitiligo TCM classification criteria, to some extent, restricted the research progress of Chinese medicine treatment of children with vitiligo.Therefore, there is very need to strengthen clinical research on childhood vitiligo each TCM syndrome distribution, in order to broaden the thinking and treatment of childhood vitiligo therapeutic approach to improve clinical outcomes.ObjectiveTo investigate the clinical syndromes characteristics of childhood vitiligo and the effect o f Gancaoxin.MethodsDiagnosed 150 childhood vilitigo patients were differentiated by the syndromes, and the n were randomly divided into two groups, the treatment group (n= 30)was treated with Gan caoxin,tacrolimus and Mometasone furoate,the control group (30 cases) was treated with tacrolimus and Mometasone furoate. Then the effects and side effects of them were observ ed. All datas were entered into the computer and analysed by SPSS20.0 statistical soft ware.ResultPart I:Analysis of TCM Syndromes in the 150 cases of childhood vilitigo1.The frequency of syndromes from high to low was confirmed:Deficiency of Spleen and Stomach Syndrome〉 Insufficient Liver and Kidney Syndrome〉 Liver-Qi Stagnation Syndrome〉 Stagnation of Qi and Blood Stasis Syndrome〉 Breeze Blood Mutually Fight Syndrome.2.In the breeze blood mutually fight syndrome and Stagnation of Qi and Blood Stasis Syndrome the proportion of male patients is larger than fe-male patients,but in insufficient liver and kidney syndrome, Stagnation of Qi and Blood Stasis Syndrome,Deficiency of Spleen and Stomach Syndrome the proportion of female patients is larger than male patients (P>0.05)3.Different syndrome types of childhood vitiligo patients in age distribution have significant difference (P<0.05).In Breeze Blood Mutually Fight Syndrome,Insufficient Liver and Kidney Syndrome and Deficiency of Spleen and Stomach Syndrome with mostly 7-12 years old patients, accounted for 50.0%,37.0% and 52.9% of the total number of their syndrome.In 2-7 and 7-12 years group with mostly Deficiency of Spleen and Stomach children.In Liver-Qi Stagnation Syndrome with mostly 12-17 years old patients.4.Different syndrome types of childhood vitiligo patients in hypopigmentation area distribution have significant difference (P<0.05).5.Different syndrome types of patients with vitiligo in clinical type distribution have significant difference (P<0.05).Every group has generalized vitiligo as the majority.6.In Insufficient Liver and Kidney Syndrome,Stagnation of Qi and Blood Stasis Syndrome and Deficiency of Spleen and Stomach Syndrome the patients of stable phese is more,accounted for 63.0%,100.0% and 61.8% of the total number of their syndrome.In breeze blood mutually fight syndrome,the stable phese and the progression are half to half. (P>0.05)Part II Clinical Observation of Gancaoxin for the Treatment of Childhood Vilitigo1.The response rate of the treatment group was 86.2%,while the controlled group was 85.7%,the latter was lower,but there was no significant difference between them. (P>0.05)2.The achieve rate of the treatment group was 10.3%, while the controlled group was 7.1%, the former was higher. But there was no significant difference between them. (P>0.05)3.The response rate was no significant difference among different TCMs type. (P>0.05)4.There was no obvious side effect during the treatment.Conclusion1.The distribution of TCM syndromes in child with vitiligo from more to less is Deficiency of Spleen and Stomach Syndrome,Insufficient Liver and Kidney Syndrome,Liver-Qi Stagnation Syndrome,Stagnation of Qi and Blood Stasis Syndrome,Breeze Blood Mutually Fight Syndrome.2.The distribution of TCM syndromes in child with vitiligo is related to the area of the hypopigmentation and the stage of vitiligo.3.Gancaoxin could significantly improved the symptom of vitiligo in children and it was no better than tacrolimus and Mometasone furoate... |
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