Clinical Epidemiological Studies Of271Children With Vitiligo

Objective: In order to understand the clinical features of childhood vitiligo andepidemiological characteristics and to provide guidance to early prevention of vitiligoby analyzing the epidemiology of271children with vitiligo and comparing withadults.Methods: The clinical cases were from patients attending dermatology in ourhospital from2009-01to2012-08.The diagnosis was made by experiencedphysicians according to the 《Clinical Dermatology》 compiled by professorZhaoBian， The form about general information and family history of patients wasregistrared by one experienced dermatologist. Childhood vitiligo patients are chosenbelow the age of12， a total of271cases， and chosing adult patients with vitiligowho are older than18years and the incidence of patients older than12years as acontrol group， the number is769cases， using SPSS13.0software to analysis andobtaine the corresponding results.Results: There were271children patients and adults patients，Males constituted50.55%(137) of the children group and females constituted49.45%(134)， The maleto female ratio is basically the same， with no significant difference. Male to femaleratio is about1:1in adult patients， no significant statistical difference.The average age of onset of childhood vitiligo patients was5.73years，it was nosignificant difference in the average age of onset between male and female children.and6-year-old is the peak age of onset with a incidence of12.91%of the total.The spring(31.37%) and summer(34.2%) were topped the list in childrenpatients，followed by the autumn and winter seasons. Compared with adults，children’s have higher incidence in autumn and winter， the difference wasstatistically significant.In the aspects of predisposing factors and aggravating factors， children’s groups predisposing factor is dematitis and the main aggravating factors is trauma anddematitis. Adult group’s main increased and predisposing factors are mental factors.there were13cases (4.80%) patients with Halo nevus in children’s group，significantly higher than the adult group， the difference was statistically significant.Children with a positive family history was accounting for19.19%， with nostatistically significant difference compared to the adult group. Family history and ageof onset， the children with positive family history whose onset average age iscompared with the children with a family history is earlyer， the difference wasstatistically significant.The most common site of vitiligo was face both in children patients and adultspatients， followed by trunk，arms and legs.A number of children vitiligo patientswho have leukoplakias in the lip area， eyelids， the vulva were20cases（7.38%），46cases(16.97%) and42cases(15.50%)，it was higher than adults patients， thedifference was statistically significant.In the originating type， localized accounted for76.75%of all patients，sporadic patients accounted for3.69%，and acral type accounted for10.70%， with asignificant difference compared with adults， respectively. Gender originating typesaffect the adult group with significant difference in the the acral type and segmentaltype aspects， but it is no significant difference in the children’s group. In treatmenttype， children’s group the majority of patients is with localized vitiligo (40.96%)，while the adult group’s the majority of patients is with sporadic vitiligo (44.70%)，the difference was statistically significant. the protortion was28.04%is the group ofchildren and in the adult group was25.61%in type conversion by localizeddevelopment of sporadic patients.The number was37(13.65%) in children patients accompanied by itching，and itis slightly lower than the adult group， the difference was statistically significant. allthe patients are in the advanced (97.36%)， the proportion was higher than thechildren without itching. The adult group’s difference is small.Conclusions: vitiligo most commonly occurs in the spring and summer;The main inducing factors were skin diseases and the main aggravating factors weretrauma and dermatitis in children group，but it was psychological factors in adults’group about inducing factors and aggravating factors; the proportion of children withhalo nevus of patients is higer than adults group. In terms of family history，19.19%of the children with a positive family history of vitiligo， the children with positivefamily history have earlier onset than children with negative family history.；Childhood vitiligo patients’ mucocutaneous junction are more likely to be involvedthan adults. In the originating type，children’s localized percentage was higher thanadult，and In treatment type， children’s group the majority of patients is withlocalized vitiligo， while the adult group’s the majority of patients is with sporadicvitiligo；Itching (especially in the children’s group) may be an indicator of theprogress of the disease.