| Chronic obstructive pulmonary disease (COPD) is a characteristics of airflow obstruction in chronic bronchitis and (or) emphysema, and associated with lung to noxious particles or gases abnormal inflammatory reaction, chronic cough, sputum, difficulty in breathing and other symptoms.COPD although is a respiratory disease, but the impact on the whole system can not be ignored, especially in patients with anxiety, depression and other negative emotions is chronic obstructive pulmonary disease (COPD) is a serious complication.COPD belongs to lung distention disease category in TCM, state anxiety in traditional Chinese medicine is a "melancholia" category. At present, with the pollution of the environment, social relations, work pressure, fuelled by the economic burden, and many other factors, the disease rate increased year by year, for the etiology of depression and anxiety in patients with chronic obstructive pulmonary disease (COPD), pathogenesis, diagnosis and treatment of also is perfect with each passing day, lay a solid foundation for seeking a better clinical efficacy.ObjectiveBy observing the treatment of tonify heart and stabilize the mind to understand the recent clinical curative effect of panic disorder. And using the Hamilton Anxiety Scale (HAMA), heart-gallbladder qi deficiency pattern of panic disorder symptoms rating scale respectively to evaluate the the onest time and clinical curative effect in different time of Chinese and western medicine treatment of heart-gallbladder qi deficiency pattern of panic disorder.MethodsIn this study, the patients with stable phase of COPD complicated with anxiety were the subjects of the study.A prospective, randomized, blinded, parallel controlled study method was used to select the standard cases of random grouping.In the test group and the control group in the treatment of "Yi Qi Yang Xin Ding Zhi Method", Radix Codonopsis, radix salviae miltiorrhizae, radix, mother of pearl, Poria, Radix Paeoniae Alba, Schisandra chinensis, Fructus aurantii, water flushes the clothing, on the agent, morning and evening service points.While the control group was given oral placebo in addition to standard therapy for chronic obstructive pulmonary disease (COPD), water flushes the clothing, a agent. Sooner or later the temperature taking.7 days for a course of treatment, continuous administration for 14 days.Before treatment,1 weeks after treatment and 2 weeks after treatment, the TCM syndrome score, Hamilton Anxiety Scale (HAMA) score, chronic obstructive pulmonary disease assessment test (CAT) were performed.All collected data were analyzed using SPSS20.0 statistical software, P<0.05 that there was a statistical difference.Results1、The score of qi deficiency heart and gallbladder type of panic disorder symptoms rating scale in every group.Two groups of gender, age, course of disease, barrel chest, dry and wet rales situation, before treatment of TCM syndrome score to quantify, Hamilton Anxiety Scale (HAMA) integral, chronic obstructive pulmonary disease assessment test table (CAT) integral between groups in the distribution differences had no statistical significance (P<0.05).2、The score of HAMA in every groupAfter treatment, the two groups of patients with traditional Chinese medicine symptom scores were significantly reduced, the symptoms were significantly improved, the onset time of the experimental group was earlier than the control group.3、The comparison of clinical efficacy between the two groupsAfter treatment, two groups of HAMA scale integral than before treatment were decreased, symptoms were significantly improved, the anxious mood, tension, fear, insomnia, muscle system symptoms, feeling system symptoms, cardiovascular system symptom improvement was significantly better than the control group, difference between the two groups was statistically significant (P<0.05).4、Comparison of therapeutic effects of CAT scale before and after treatmentCAT scores were decreased after treatment in the two groups, but in test group in 7 days after treatment score lower on significant difference (P<0.05), while the control group is in 14 days post treatment scores did not decrease with significant difference (P<0.05), which could show that the treatment effect of better efficacy of the test group, the experimental group is better than that of control group.5、The clinical efficacy was compared between the two groupsBasis for quantitative TCM syndrome score evaluation standard, after 2 weeks of treatment, the total efficiency of the two groups were compared:test group a total of 31 cases, clinical cure in 3 cases, markedly effective in 17 cases, effective in 11 cases, invalid 1 case, the total efficiency was 96.77%; there were 32 cases in the control group, clinical cure 0 cases, markedly effective rate was 4 cases and effective for the 20 cases, invalid in 7 cases, the total efficiency was 77.42%. The experimental group of TCM Syndromes of the total efficiency was significantly better than the control group of TCM syndrome total efficiency, the difference between the two groups has statistical significance (P< 0.05).After 2 weeks of HAMA total efficiency:test group of 32 cases, clinical cure in 6 cases, markedly effective in 20 cases, effective in 3 cases, invalid 3 cases, the total efficiency was 90.63%; the control group 31 patients, clinical cure for 0 cases, markedly effective in 15 cases, effective in 10 cases, invalid in 6 cases. The total effective rate was 80.65%. The experimental group of HAMA total efficiency is obviously superior to the control group of HAMA total efficiency, the difference between the two groups has statistical significance (P< 0.05).According to the criteria for evaluation of curative effect of the cat, cat in the day 7,14 treatment, the test group total efficiency is obviously superior to the control group, the difference between the two groups has statistical significance (P< 0.05).6、Security comparisonAnalysis of two groups of drug safety in 4 weeks of treatment, two groups of patients vital signs (including heart rate, body temperature, blood pressure, respiration and other), blood, urine routine, liver and kidney function test results and ECG examination results showed no obvious abnormalities.And the two groups of patients with adverse drug reactions mainly for thirst, sweating, sleep, depending on the matter is not clear, diarrhea and so on.ConclusionSatisfactory clinical results were obtained in two groups of patients, but compared with the control group, the test group can early remission in patients with chronic obstructive pulmonary disease symptoms and symptoms of anxiety and depression and clinical curative effect is obviously superior to the control group. Tips to Yangxin Yiqi Dingzhi method to improve the clinical research of chronic obstructive pulmonary disease patients’ anxiety state is safe and effective. |
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