Boiling Powder Craft Research And Pharmacodynamic Analysis Based On Ganjiang Huangqin Huanglian Renshen Tang Clinical Efficacy

ObjectiveGanjiang Huangqin Huanglian Renshen Tang boiling powder craft research and a preliminary analysis of the efficacy of T2DM rats.MethodsProfessor Tong xiaolin appliy with Ganjiang Huangqin Huanglian Renshen Tang basis for clinical experience,and then conduct further on Ganjiang Huangqin Huanglian Renshen Tang clinical observation.Selection of radix scutellariae, rhizoma coptidis, American ginseng, rhizoma anemarrhenae, rhizoma zingiberis5boiled powder preparation technology was studied Chinese medicine yinpian, choose three kinds of particles size, according to pharmacopoeia standard by the method of HPLC determination of content and dry paste rate research single medicine yinpian crushing degree;travel through the dry paste rate determination and the effective composition content determination method is boiled powder and the traditional yinpian relationship on single herbs and compound; Through the animal experiments to compare the pharmacodynamics, finally draws the conclusion.Animal experiments using SD rats a high-fat feeding in combination with small dose of intraperitoneal injection of STZ, get the T2DM rats model, divided into model group, western medicine group, yinpian group, boiled powder group, two-thirds yinpian group, two-thirds boiled powder group, respectively with pure water, metformin, medicinal broth of yinpian medicinal broth, boil, two-thirds yinpian medicinal broth, two-thirds of boil one lavage12weeks, the normal group with amount of pure water to fill the stomach, the determination of weight, fasting blood glucose (FBG), glycosylated hemoglobin (GHB), and other indicators, using the single factor analysis of variance contrast each dosage group after the treatment effects on blood sugar.ConclusionClinical observation of this study are Ganjiang Huangqin Huanglian Renshen Tang was significantly more effective, and this study concludes that the prescriptions in particle size on the choice of rhizoma coptidis, radix scutellariae, ginseng, rhizoma anemarrhenae, boiled powder particles, Less than10mesh particles larger than80mesh in the total proportion of not less than80%,dried ginger boiled powder particles Less than10mesh particles larger than60mesh in the total proportion of not less than80%; From single herbs analysis, and compared the two methods of decoction of yinpin, boiled powder decoction of dry paste rate of active ingredients and the solution was higher than that of traditional yinpian, quickly and in a relatively short time to release the main effective components. From compound research, according to the results of the water decoction effective component content determination of the whole party to boiled powder than conventional decoction slices, Fried out high amount of effective ingredients, and can save about a third of medicinal materials, and boiled powder less than yinpian decoction, condense the time required, more energy saving.High-fat feeding in combination with small dose of STZ (streptozotocin) can successfully induce the SD rat model of type2diabetes mellitus. For12weeks in March in lowering blood sugar, two-thirds of boiled powder group is superior to2/3yinpian, and no significant difference with yinpian group namely Two-thirds of boiled powder about equal yinpin on the curative effect, thus it can infer, boiled powder can save about a third of the amount of yinpin. In terms of lowering glycated hemoglobin, there was no statistical significance between the treatment group, which may be observed no significant change in a short time about glycated hemoglobin. In this experiment, a valid basis Ganjiang Huangqin Huanglian Renshen Tang, through the pharmaceutical research and animal experiment showed that boiled powder is better than that of yinpian, under the precondition of guaranteed results boiled powder relative to the yinpian can save1/3quantity of medicinal materials, and can save energy consumption.