Analysis Of BCAP Gene Polymorphism For Patients With Allergic Rhinitis Of Hui And Han Ethnics In Ningxia

Objective To discovery of Ningxia Hui and Han Chinese population BCAPrs505010gene frequencies in patients with allergic rhinitis and the normalpopulation, and to explore the relationship between allergic rhinitis and the genepolymorphism.Methods We selected300AR patients in the Ningxia epidemiologicalinvestigation of allergic rhinitis, according to a history of allergic rhinitis, typicalsymptoms and skin prick test and other test results confirmed as AR. We selectedhealthy normal controls300cases that have no medical history and family history ofallergic rhinitis. We used polymerase chain reaction and direct sequencing of the geneto discovery the control group and the Case group with BCAP gene loci rs505010,analysis to compare the gene and allele frequencies. And the frequencies of genotypesand alleles of the SNPs were tested by Hardy-Weinberg equilibrium.Results There is polymorphism in BCAP gene rs505010loci of Hui and HanChinese people in Ningxia and genotypes were homozygous wild-type TT,heterozygous CT, homozygous polymorphism CC. The difference in the frequenciesof genotypes and alleles between case and control groups, or between the case groupand the control group in the Hui and Han Chinese people,or between the Han and HuiChinese people in the case group, was not statistically significant (P>0.05); Overalldistribution of allele frequencies and genotype frequencies of the gene is basicallysame in Hui, Han normal control group.Conclusions BCAP gene loci rs505010exists polymorphism mutation, but ithas no significant correlation with the susceptibility of AR of Hui and Han Chinesepeople in Ningxia.