Effects Of Tongmai Granules On Serum Cystatin C To Coronary Atherosclerosis Patients With Qi-deficiency And Blood-stasis Syndrome

Objective:To observe the effect of Tongmai granules on serum cystatin C of coronary atherosclerosis patients with Qi-deficiency and blood-stasis syndrome, explore the mechanism of "Tongmai granules" for coronary atherosclerosis with Qi-deficiency and blood-stasis syndrome.Methods:80coronary atherosclerosis patients diagnosed by coronary angiography with Qi-deficiency and blood-stasis were randomly divided into2groups.In the Tongmai granules group,Tongmai granules were two doses twice per day taken with water. The treatment was4weeks.In the western medicine group,aspirin enteric-coated sustained release tablets were taken100mg once per night, and atorvastatin calcium tablets were taken20mg once per night. The treatment was4weeks. Detecting coagulation function, glucose, cardiac function, liver and kidney function, blood-lipid, blood routine, stool routine, defecate occult blood,urine routine and the score of Qi-deficiency and blood-stasis symptom respectively before and after the treatment.Results:1.There were no significant difference between Tongmai granules group and control group in serum cystatin C, blood-lipid and TCM symptom before the treatment (p>0.05).2.Serum cystatin C was significantly increased in two groups after4weeks’ treatment.Compared with before treatment was statistically significant (p<0.05).3.Blood-lipid showed significant difference in Tongmai granules group(p<0.05), and significantly decreased in western medicine group after4weeks’treatment (p<0.05), with significant difference between groups (p<0.05). Western medicine group showed a better effect in decreasing blood-lipid.4.The curative effect of TCM symptoms of Tongmai granules group and western medicine group were89.47%and57.90%respectively, with significant difference between groups (p<0.05). Tongmai granules group was significantly better than control group.Conclusion:1.Tongmai granules can increase levels of serum cystatin C of coronary atherosclerosis patients with Qi-deficiency and blood-stasis syndrome.2.Tongmai granules is significantly better than control group in improving TCM symptoms of coronary atherosclerosis patients with Qi-deficiency and blood-stasis syndrome.3.Tongmai granules has no adverse reactions and side effects in therapeutic doses.