| Objective: To observe the clinical efficacy of self-designed Buqi Tongmai Decoction in the treatment of chronic coronary syndrome with qi deficiency and blood stasis after PCI.Methods: A total of 64 patients with qi-deficiency and blood-stasis type chronic coronary syndrome after PCI were included in this study,and they were randomly divided into treatment group and control group(32 cases in each group).There was no significant difference in age,gender,BMI and other general information between the two groups.The control group was treated with standardized treatment of Western medicine,and the treatment group was treated with self-prepared Buqi Tongmai decoction on the basis of standardized treatment of western medicine.The course of treatment was 4 weeks.By observing the changes of angina pectoris symptoms,traditional Chinese medicine symptoms,Seattle Angina pectoris scale score,nitroglycerin withdrawal rate,blood h S-CRP,Hcy level,brachial artery flow-mediated vasodilation function(FMD)and safety indicators(general vital signs,liver function and renal function)in 2 groups before and after treatment.To evaluate the clinical efficacy and safety of self-prepared Buqi Tongmai decoction.Results: A total of 64 cases were included in this clinical experiment.After the actual 4-week course of treatment,excluding the cases of elimination and shedding,a total of 61 patients completed the course of treatment and data statistics,including 30 cases in the treatment group and 31 cases in the control group.1.Angina symptom score and TCM syndrome score of patients in the treatment group and the control group were significantly lower before and after treatment than before treatment(P<0.05),and the treatment group was superior to the control group(P<0.05).In the treatment group,the total effective rate of angina pectoris symptom curative effect,TCM symptom curative effect and nitroglycerin withdrawal rate were 80.00%,83.33% and 83.33%,respectively,while in the control group,the total effective rate of angina pectoris symptom curative effect,TCM symptom curative effect and nitroglycerin withdrawal rate were 67.74%,74.19% and 61.29%,respectively.Comparison of angina pectoris symptom efficacy,TCM symptom efficacy and nitroglycerin withdrawal rate between the two groups showed statistically significant differences(P<0.05),indicating that the treatment group was superior to the control group in improving angina pectoris symptom efficacy,TCM symptom efficacy and nitroglycerin withdrawal rate.2.Seattle angina questionnaire scores before and after the treatment,two groups after treatment limited physical activity level(PL),angina,steady state(AS),angina(AF),treatment satisfaction(TS),degree of disease cognition(DP)of five dimension score was significantly increases,the have a statistically significant difference(P < 0.05).After treatment,the scores of PL,AF,AS and TS in the treatment group were higher than those in the control group,and the differences were statistically significant(P<0.05),while there was no significant difference in DP scores between the two groups(P>0.05).The results showed that both the treatment group and the control group could improve PL,AF,AS,TS and DP,and the treatment group had significant advantages in improving PL,AF,AS and TS compared with the control group.3.After treatment,the levels of h S-CRP and Hcy in the treatment group and the control group were significantly lower than before treatment,with statistical significance(P<0.05).After treatment,the levels of h S-CRP and Hcy in the treatment group were lower than those in the control group,and the differences were statistically significant(P<0.05).These results indicated that both the treatment group and the control group could effectively reduce the levels of h S-CRP and Hcy in blood,and the treatment group was better than the control group in reducing the levels of h S-CRP and Hcy in blood.4.After treatment,the brachial artery flow-mediated vasodilation function(FMD)was significantly increased in both groups compared with before treatment,and the difference was statistically significant(P<0.05).After treatment,the treatment group improved the level of brachial artery flow-mediated vasodilation(FMD)better than the control group,and the difference was statistically significant(P<0.05).It indicates that both the treatment group and the control group can improve FMD,and the treatment group is significantly better than the control group in improving FMD.5.Before and after treatment,the general vital signs(body temperature,respiration,pulse,heart rate and blood pressure),liver function and kidney function of 2 groups were all within the safe range,and there was no statistical significance between the two groups(P>0.05).It indicates that the treatment group and the control group are safe and reliable in the treatment process. |
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