The Impact Of Pinopodes And HB-EGF By Bushen Chinese Herbs For The Patients Inadequate Luteal Function On Their Endometrial

Objective: Explore Bushen Chinese herbs of ErzhiTiangui particles to the kidney lutealfunction is not healthy embryo implantation in patients with endometrial pinopodes,HB-EGF, and to explore its therapeutic effects and mechanisms of endometrial receptivity.Method:66patients with kidney luteal function is not healthy infertility patients wererandomly divided into two groups, a group of two to ErzhiTiangui particles (treatmentgroup)33cases, the other group (placebo group)33cases. ObservationThe TraditionalChinese medicine syndromes improvement after the treatment of the two groups ofpatients,the levle of embryo implantation serum estradiol (E2), progesterone (P),usescanning electron microscopy to observation the form and amount of embryo implantationperiod endometrial pinopodes, Observed with immunohistochemical methodsheparin-binding epidermal growth factor(HB-EGF), Comparison Embryo implantationperiod in the two groups of patients before and after treatment Endometrial thickness, type,blood flow, and pulsatility index (IR) and resistance index (PR) by Bounce tester.Results:(1) The treatment group with traditional Chinese medicine and kidney syndromesimprovement than the placebo group.(2) embryo implantation treatment group serumestradiol E2and progesterone P values were higher than the placebo group.（3）Treatmentgroup endometrial thickness greater than the placebo group；treatment group endometrialmarked increase in the number of B-type;Treatment group endometrial blood flowresistance index (RI), pulsatility index (PI) after treatment was significantly lower;endometrial blood flow improved significantly.(4) Treatment group endometrialheparin-binding epidermal growth factor (HB-EGF) positive expression than in the placebogroup.(5) treatment Group pinopode the cell surface to form a smooth, thin endometrium projection, fully developed pinopodes, more rich. the placebo group is small less and notrich.Conclusion: ErzhiTiangui particle treatment of kidney luteal function is not healthyinfertility may be related to enhanced positive expression of endometrial heparin-bindingepidermal growth factor (HB-EGF) and increase the endometrial pinopodes number,Improve the morphology pinopodes.