Study On The Relationship Between Hyperuricemia And Lipid Metabolism-Related Indicators

Objective:To investigate the prevalence of hyperuricemia and its risk factors in the adult population aged35～70years, and the association between hyperuricemia and lipid metabolism-related indicators.Methods:To analyze data of3122residents from the cross-sectional survey. In this study, subjects were recruited from baseline study population in Changzhou city, Jjiangsu province, which was the integral part of PURE study. SAS9.2software was used to find the risk factors of hyperuricemia. We also compared the level of lipid metabolism-related indicators in people with hyperuricemia and normal population, and analyzed relationship between serum uric acid levels and these indicators.Results:(1) The prevalence of hyperuricemia was18.35%,26.83%for man and11.90%for women, respectively (P<0.0001). The mean level of uric acid in males was higher significantly than that in the females [(373.17±109.56),(292.23±99.03) umol/L, P<0.0001].(2) Totally, the prevalence of hyperuricemia was increased with the age(Z=3.6684, P=0.0002). In male population, serum uric acid and prevalence of hyperuricemia were declined with the age (Z=1.0428, P=0.297), but not in female population (Z=6.3351, P<0.0001)(3) The main concomitant diseases of hyperuricemia were hyperlipemia (78.9%), then hypertention (37.70%), abdominal obesity (37.70%), diabetes (8.03%,) respectively.(4) Subjects with the hyperuricemia had higher age, ALT(Alanine Aminotransferase), fasting glucose, serum creatinine, total cholesterol, triglyceride, LDL-C(Low Density Lipoprotein Cholesterol), C-reactive protein, insulin, SBP(Systolic Blood Pressure), DBP(Diastolic Blood Pressure), BMI(Body Mass Index), waistline, hips than normal population (P<0.0001).(5) Rank correlation analysis was showed that serum uric acid had significant correlation with ALT, serum creatinine, total cholesterol, triglycerides,LDL-C, insulin, C-reactive protein and fasting-glucose levels, respectively.(6) After performing the multivariate logistic regression model, we found that male gender (OR=3.007,95%CI:2.25-4.03), drinking alcohol (OR=1.387,95%CI:1.06-1.81), hypertention (OR=1.335,95%CI:1.07-1.66), abdominal obesity (OR=1.795,95%CI:1.43-2.26), hyperlipidemia (OR=1.412,95%CI:1.06-1.88), brothers and(or) sisters hypertention (OR=1.383,95%CI:1.05-1.83) were associated with the increased risk of hyperuricemia.Conclusion:(1) male gender, drinking alcohol, hypertention, abdominal obesity, hyperlipidemia and brothers and (or) sisters hypertention are associated with increased risk of hyperuricemia.(2) hyperuricemia was associated with lipid metabolism-related indicators.