Study On The Prevalence And Influencing Factors Of Hyperuricemia In Adult Physical Examination Population In Hefei Area From 2017 To 2020

Objective:To understand the change trend of blood uric acid level and prevalence of hyperuricemia among adult physical examination population in Hefei from 2017 to2020,analyze the population distribution characteristics and related influencing factors,and provide basis and guidance for the prevention and treatment of hyperuricemia.Methods:Using a cross-sectional study method,178535 study subjects aged≥18 years who underwent health examinations at the Physical Examination Center of the First Affiliated Hospital of Anhui Medical University from January 2017 to December 2020were selected through inclusion and exclusion criteria screening,including 101319males and 77216 females.The height,weight and blood pressure of the subjects were collected through physical examination,and the body mass index(BMI)was calculated.Collect the blood indicators of the subjects through laboratory tests,including uric acid(UA),fasting plasma glucose(FPG),creatinine(CREA),urea(UREA),total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C)Low density lipoprotein cholesterol(LDL-C),alanine aminotransferase(ALT),aspartate aminotransferase(AST),direct bilirubin(DBIL),indirect bilirubin(IBIL),white blood cell(WBC)count,etc.SPSS 22.0 software was used for statistical analysis,and P<0.05indicates a statistically significant difference.Results:1.The overall prevalence of hyperuricemia in this study was 16.1%,which was higher in men than in women(22.5%vs.7.7%,χ~2=7107.462,P<0.001).From 2017 to 2020,the prevalence rates in each year were 15.9%,12.8%,17.9%,and 22.5%,of which21.6%,18.3%,25.7%,and 30.4%were males,and 7.3%,5.5%,8.5%were females.%,12.9%,both showed a trend of first decreasing and then increasing.2.There were significant statistical differences(P<0.001)in the proportion of dyslipidemia,hypertension,decreased glomerular filtration rate,and increased fasting glucose between hyperuricemia and normouricemia groups combined with normal serum uric acid in terms of systolic blood pressure,diastolic blood pressure,body mass index,white blood cell count,urea,GFR,total cholesterol,triglycerides,HDL cholesterol Differences in LDL cholesterol,fasting glucose,alanine aminotransferase,aspartate aminotransferase,and direct bilirubin were statistically significant(P<0.001).3.The serum uric acid level and the prevalence of hyperuricemia showed a decreasing trend first and increasing with year,regardless of men or women.The prevalence of hyperuricemia in men was higher than that in women in all age groups 18-69 years and lower than that in women≥80 years(P<0.001),and the prevalence in both age groups70-79 years was close with no statistical difference(P=0.662).4.The differences in blood uric acid levels between different seasons were statistically significant(P<0.001).The prevalence of blood uric acid levels and hyperuricemia in summer and autumn were higher than those in spring and winter(P<0.001),and males were higher than females(P<0.001).5.Multivariate linear regression analysis showed that blood uric acid and systolic blood pressure,body mass index,white blood cell count,total cholesterol,triacylglycerol,low-density lipoprotein cholesterol,alanine aminotransferase,and direct bilirubin were independent for both males and females.Positive correlation(P<0.05),and independent negative correlation with age,diastolic blood pressure,glomerular filtration rate,high-density lipoprotein cholesterol,and fasting blood glucose(P<0.01).Multivariate logistic regression analysis showed that male,hypertension,high total cholesterol,high triglycerides,high low density lipoprotein cholesterol,low high density lipoprotein cholesterol,decreased glomerular filtration rate,white blood cell count,alanine amino group Transferase and direct bilirubin are risk factors for hyperuricemia,while elevated fasting blood glucose is a protective factor for hyperuricemia.As weight gains,the risk of hyperuricemia gradually increases;young people and elderly people≥80 years of age are more likely to develop hyperuricemia.Conclusion:The overall prevalence of hyperuricemia and the prevalence of both genders in Hefei from 2017 to 2020 showed a first decreasing and then increasing trend,and the same trend was observed for serum uric acid levels.The serum uric acid level and the prevalence of hyperuricemia in both sexes decreased first but then increased with age,but the prevalence in men was highest in the age group 18-29 years,whereas the prevalence in women increased markedly after menopause,and the prevalence in men exceeded that in men in the age group 70-79 years,reaching 30.3%.Thus,the risk was significantly higher in young males and older adults.Between 2017 and 2020,the median serum uric acid level showed obvious seasonal variations,and the serum uric acid level and prevalence of hyperuricemia were higher in summer and autumn than in spring and winter,and higher in men than in women in each season.Male gender,obesity,hypertension,dyslipidemia,and reduced glomerular filtration rate were all risk factors for hyperuricemia,whereas elevated fasting glucose was protective.