Change On The Prevalence Of Hyperuricemia Between 2000 And 2009 In A Community-based Elderly Population In Beijing

Objectives:To explore the change on the prevalence of hyperuricemia and its risk factors in a community-based aged population in Beijing over 10 years period.Method:The study populations were derived from the Beijing Longitudinal Study of Aging, conducted by the Social Medical Department of Xuanwu Hospital. A stratification-random-clustering procedure was designed to ensure the representativeness of the average education and economic level in Beijing in 2000. A similar survey was conducted in 2009. All of the individuals answered a uniform questionnaire and underwent physical examinations via face-to face interviews. Demographic data and lifestyle information were collected. Blood samples were collected in 2000 and 2009. A total of 2 191 subjects in 2000 and 1485 subjects in 2009 were enrolled in the current study. This study investigated trends of uric acid levels, hyperuricemia morbidity among the elderly. and finaly, the risk factors of HUA were explored. Serum uric acid >357umol/L in females or >420umol/L in males was diagnosed as hyperuricemia. Another two diagnosis criteria(serum uric acid >420umol/L in both males and females and serum uric acid >357umol/L in both males and females) were applied in these subjects.Results: 1.The total prevalence of hyperuricemia increased from 9.7% to 21.1% from 2000 to 2009(P<0.01). And the prevalence of hyperuricemia increased from 9.7% to 17.5% in men(p<0.01) and from 9.8% to 23.9% in women(p<0.01), respectively. The prevalence of hyperuricemia increased in every age_subgroup(55-69 years old, 70-79 years old, 80-years old) in both men and women from 2000 to 2009.2. Mean uric acid levels increased from 2000 to 2009(318.3umol/L vs 272.8umol/L). The levels of UA rised in both genders(299.2 umol/L vs 340.7umol/L in men and 246.2umol/L vs 300.1 umol/L in women).Mean uric acid levels increased in every age_subgroup in both men and women from 2000 to 2009. 3.Multivariate logistic regression models revealed hyperuricemia was positively associated with hypertension, overweight/ obesity, dyslipidemia, urban residents or metabolic syndrome. The risk of HUAprevalent increased greatly with the number of Mets components cummulation.Conclusion: Serum uric acid levels and prevalence of hyperuricemia increased remarbly in Beijing community-based population over 10 years period. The prevalence of hyperuricemia and the levels of UA increased in every age_subgroup(55-69 years old, 70-79 years old, 80-years old) in both men and women in this period. After control potential risk factors, itrevealed hyperuricemia prevalent was positively associated with hypertension, overweight/obesity, dyslipidemia, urban residents. With the increasing number of metabolic syndrome components, the risk of HUAprevalent increased remarkbly.