Based On The Theory Of Collaterals Disease Pulmonary Fibrosis Syndrome Of Traditional Chinese Medicine Study

Objective:Based on collateral disease theory, to observe the TCM syndrome distribution characteristics of pulmonary interstitial fibrosis in patients with varying degrees, to analysis the syndrome feature of gas network and blood collateral, and to explore its pathogenesis and transformation for guiding clinical diagnosis and treatment.Methods:Collected96cases of pulmonary interstitial fibrosis patients with basic information, clinical symptoms and signs, results of physical and chemical tests, and established the corresponding EXCEL database. Based on the individual physical and chemical examination and CRP synthesis score, all the patients were divided into mild patients, moderate patients and severe ones. Selected an objective and reliable classification method for summarizing common TCM syndromes and each classification constituent ratio of the patients, then applied SPSS17.0statistical software to analysis the relatively major syndromes occurrence differences in the mild, moderate and severe patients.Results:Comparing the evaluation methods, CRP synthesis score was considered as the most objective method. By this method, the96cases of patients were classified into24cases (24.25%) of mild,46cases (46.48%) of moderate and26cases (26.27%) of severe. The gender and age had no statistical correlation to the classification effect but the course of disease.There was no significant difference between the patients contacted poison and the ones incidence of contact. Deficiency syndrome, phlegm syndrome and blood stasis were the most basic syndrome types, the proportion was100%,51.04%and61.46%respectively. The most proportion in deficiency was Yin deficiency (69.79%), followed by Qi deficiency (65.63%), among which lung and spleen Qi deficiency and lung Yin deficiency accounted the most, that were29cases (30.21%),32cases (33.33%). The most proportion in demonstration was blood stasis (61.46%), followed by phlegm retention syndrome (32.29%). Individual as the object of study, there were67cases (69.79%) with the syndrome of intermingled deficiency and excess, among which deficiency、phlegm and blood stasis seen at the same time occurred most, a total of37cases (38.54%). There were29cases(30.21%) of a single deficiency and no full demonstration.In mild patients, the highest proportion was lung Qi deficiency(37.5%), in moderate patients was lung Yin deficiency (52.17%), lung and spleen Qi deficiency (45.56%), and in patients with severe, proportion of blood stasis was up to84.62%the phlegm syndrome accounted76.92%, lung and kidney Yin deficiency accounted73.08%, spleen and kidney Yang deficiency syndrome, lung, spleen and kidney deficiency accounted34.62%each.From mild to severe, a gradual transition was from lung and spleen to kidney, the deficiency types involved increased gradually. Among them, the deficiency syndrome involved one or two types were mainly distributed in patients with mild to moderate patients. While severe patients mainly had double or three deficiency syndrome.Conclusion:Pulmonary interstitial fibrosis patients with different degrees had varied features, Qi and Yin deficiency. blood stasis run through the whole course. While the mild ones were given priority to lung Qi deficiency, the moderate ones were given priority to lung and spleen Qi deficiency and lung Yin deficiency, the severe ones were lung and kidney Yin deficiency and phlegm and blood stasis. The lung collaterals were deficiency, phlegm and blood stasis blocking lung collaterals were the basic pathogenesis of pulmonary fibrosis. First,the lung collaterals were deficiency,then toxin factor attacked, that was a process from virtual to stagnation and the virtual increasing at the same time. The toxic evil both included smoke poison, dust toxic, drug toxic, radioactive poison there of, also each knot of phlegm and blood stasis poison within the lung. The evolution of the disease follow the changes from pulmonary gas network to pulmonary blood vessels. The syndromes of pulmonary gas network was characterized by lung and spleen Qi deficiency and lung Yin deficiency, whereas pulmonary blood collateral was characterized by phlegm and blood stasis and lung and kidney yin deficiency as the central expression.