Based On The Theory Of "dry Blood", The Study Of The Clinical Characteristics Of Patients With Pulmonary Fibrosis Of Blood Stasis Syndrome

ObjectivePre-exploration of the hypothesis of "dry blood" theory of pulmonary interstitial fibrosis,the diagnostic criteria of pulmonary interstitial fibrosis’ dry blood syndrome has been formed.By collecting and analyzing the clinical data of patients with pulmonary interstitial fibrosis,the relationship between the degree of blood stasis and the severity of patients with pulmonary interstitial fibrosis has been proved.Besides,the content of the new diagnostic criteria for dry blood has been tested,aimed to explore the relationship and difference between "blood stasis"and "dry blood",as well as looking into the special meaning of "dry blood" to pulmonary interstitial fibrosis.BackgroundThe morbidity and mortality of pulmonary interstitial fibrosis are increasing globally,endangering human health.Traditional Chinese medicine has unique insights and clear curative effects on this disease.Many TCM doctors think that blood stasis of pulmonary is one of the key to its pathogenesis.Based on the above research,we propose the theory of "dry blood" of pulmonary interstitial fibrosis and think that patients with this disease The blood stasis of the lungs with this disease have the same characteristics as "dry blood" which is described by Zhang Zhongjing and may develop to "dry blood".MethodsA cross-sectional study was used in this research.The included patient should fit the diagnosis of pulmonary interstitial fibrosis and the diagnosis of blood stasis in TCM syndrome at the same time.Their general information,main symptoms,information on the four diagnosis of TCM,quality of life score,HRCT semi-quantitative score and lung function Indicators has been collected,and this information has been analysis by statistics’method like descriptive statistics,chi-square test,factor analysis and cluster analysis,correlation analysis and so on The distribution and regularity of clinical characteristics of TCM and Western medicine in patients with pulmonary stasis fibrosis of blood stasis syndrome is going to be analyzed.The correlation of the severity of the disease is going to be analyzed.Through theoretical research,the diagnostic criteria of pulmonary interstitial fibrosis’ dry blood syndrome is going to be summarized and this criteria is going to be proved.Results1.The participants has more male than female,and more common in the elderly,.It is concentrated in the age group of 51-80 years old,and its combined diseases are more common in the circulatory system,autoimmune system,respiratory system,and endocrine system.2.The four main symptoms of cough,expectoration,shortness of breath,and wheezing are widely present in the participants and most of the four main symptoms are combined in the participants.In addition,symptoms such as fatigue,dry mouth,chest tightness,and anorexia appear more often Besides,many participants share slow onset and long duration,and their symptoms easy to exacerbate after work and tiredness.Pulse strings,thin,slippery tongue,dark red fur and white greasy tongue also appear more often.3.Spleen deficiency dampness,yang deficiency and blood stasis,lung and kidney deficiency,qi deficiency blood stasis and lung and spleen deficiency,deficiency of qi and yin,phlegm and stasis internal resistance are the main TCM syndromes of patients with pulmonary interstitial fibrosis type.TCM syndrome differentiation analysis shows that lung,kidney,spleen,qi deficiency,yang deficiency,phlegm,blood stasis,qi stagnation,etc.are common syndromes,including lung,heart disease,phlegm,blood stasis and qi deficiency,blood deficiency,yin deficiency,Yang deficiency is closely related to the severity of the disease;kidney,spleen,heart,lung,stomach disease,phlegm,stagnation and Yang deficiency,Yin deficiency,blood deficiency and blood stasis are closely related.4.The correlation between the severity of blood stasis and the main symptoms of cough,expectoration,shortness of breath,wheezing and quality of life HRCT semi-quantitative score in patients with pulmonary interstitial fibrosis is statistically significant.5.According to the theoretical research,the hypothesis of the criteria for udging the dried blood of patients with pulmonary interstitial fibrosis is summarized as follows:(1)the syndrome differentiation is in accordance with the blood stasis syndrome differentiation;(2)the syndrome differentiation has deficiency factors;(3)There are thermal factors in syndrome differentiation;(4)collateral factors in the disease location;(5)long course of disease,unsatisfactory improvement in symptoms after treatment(Chinese medicine for promoting blood circulation and removing blood stasis);(7)having the following symptoms or signs:1)Skin nail error 2)Dark eye area 3)Abdominal fullness or abdominal pain 4)Anorexia 5)Weight loss 6)Chest tightness 7)Chest pain.And the appearance,development,and treatment improvement of the above factors should be related to the condition of the main disease of pulmonary interstitial fibrosis.6.Validate the hypothesis of dried blood judging criteria through correlation analysis with the severity of the disease,including deficiency syndromes(including deficiency of qi,yang deficiency,blood deficiency,and loss of essence),chronic disease and skin nail errors,anorexia,dark eyes,etc It is related to the severity of the disease.ConclusionsLiterature collation and theoretical discussion indicate that blood stasis in participants is closely related to "dry blood".Statistical analysis of the clinical characteristics of the participants found that deficiency,phlegm,and stasis are the key to the pathogenesis of the disease.The degree of blood stasis syndrome is positively correlated with the severity of the disease.Hypothesis of maj or pathological factors in patients with fibrosis.In the hypothesis of the judgment standard for dried blood,factors such as deficiency syndrome,chronic illness,skin nail errors,anorexia,and dark eyes are correlated with the severity of the patient’s condition,which can guide the judgment of dried blood in patients with pulmonary.interstitial fibrosis significance.