Efficacy Of Somatostatin In Adhesive Intestinal Obstruction

Objective:To assess the efficacy of somatostatin in adhesive intestinal obstruction.Methods:All patients within Gansu people’s Hospital from January2011to January2012were conducted. They were randomized into two groups:control group and somatostatin group by means of random number table. The control group were received conventional treatment, including fasting, gastrointestinal decompression, acid suppression, total parenteral nutrition and application with enema, and the somatostatin group used somatostatin on the basis of conventional treatment (somatostatin3mg+NS250ml, the first5min inject0.25mg, then intravenously by infusion pump and the drop speed with0.25mg/h). Some aspects were analyzed between the two groups, which includes the remission time of abdominal pain and distention. anal exhaust time, fasting time, length of hospital days, the average of gastrointestinal decompression, operative rates, we also measured the level of GLN/DAO/MDA and judge the degree of recovery of intestinal mucosal barrier. We also assessed the score of SAPS Ⅱ between two groups.Results:83patients were randomized to the control group (43) or the somatostatin group (40). Patients’demographic data and clinical presentation were equal in the two groups. After treatment, the clinical symptoms and the level of intestinal mucosal barrier, and the score of SAPS Ⅱ also were significantly improved in the somatostatin group(p<0.05).Conclusion:Somatostatin could reduce patient’s clinical symptoms recovery time, reduced operative rates and restored the intestinal mucosal barrier. Therefore, it is a good alternative to prognosis of adhesive intestinal obstruction.