RVVC Patients Clinical Study Of Integrative Therapy And Vaginal Immune Status

Purpose:The pathogenesy of recurrent vaginal Candida infections are poorly understood. Pathogen virulence and host immunity is generally belived to play an important role in the occurrence of the disease. Local innate immunity might be the major host immune defense mechanisms of mucosal candida infections. The efficacy of clinical antifungal to the single incidence of RVVC is reliable,, but does not prevent its recurrence. In this study, we want to konwe the clinical efficacy of the joint of fluconazole and Baofukang suppository in reducing the recurrence rate of RVVC,and by observing the changes of vaginal immune factors in RVVC patients and normal control group,to explore the changes in vaginal immune status of the RVVC patients. Thus for the pathogenesis and treatment of RVVC provide clinical basis.Methods:40cases of RVVC patients were randomly divided into Baofukang suppository group and clotrimazole suppositories group. And collection of vaginal lavagei in the treatment of Gynecological.40cases of patients were treated with initial treatment and maintenance therapy treatment. Initial treatment:Baofukang suppository treatment group received fluconazole150mg Dayton clothing, and vaginal packing Baofukang suppository,1/day,7days in a row. Clotrimazole treatment group received fluconazole15omg Dayton clothing, and at the same time vaginal filling clotrimazole vaginal suppository of150mg/day for7days. Seven days after the end of the treatment line anew collect the vaginalsecretions and make the bacteriology examination. Positive repeat above treatment, wait until the bacteriological examination was negative then enter maintenance therapy. However, if the two courses of treatment bacteriological examination is still positive then removed the object of study. Bacteriological examination of the negative directly into themaintenance therapy. Maintenance treatment in the luteal phase of the menstrual, and treatment of three consecutive menstrual cycles. Baofukang suppository group was given Baofukang suppository, one a day, seven days in a row; Clotrimazole suppositories group was treated with clotrimazole vaginal suppositories150mg, one a day, seven days in a row. Each group of treatment of three consecutive menstrual cycles, the last menstrual cycle to the end of treatment7days review the bacteriological examination and collection of vaginal lavage fluid. Afer the end of the maintence phase treatment, Withdrawal the7th day and the1,2,3,5,6menstrual cycle follow-up. The normal control group of healthy women of40cases of medical, the collection of vaginal lavage fluid when Gynecological. All vaginal lavage fluid collected from the ELISA experiments to detect the concentration of SIgE,IL-10, IL-2, IL-8.Results:1. RVVC group before treatment, the vaginal lavage fluid IL-8, IL-10expression level was significantly higher than the normal control group, have significant difference (P<0.05);but vaginal lavage fluid IL-2, SIgE expression levels between the two non-significant difference, Not statistically significant (P>0.05); After the withdrawal, IL-2, The SIgE, IL-10, IL-8expression level of the vaginal lavage fluid between RVVC group and the normal control group showed no significant difference (P>0.05).2.38cases of patients completed the clinical treatment and follow-up, Baofukang suppository group after initial treatment.clinical recovery rate of20%, markedly effective rate of65%, the total efficiency of85%; Clotrimazole suppositories group after the initial treatment of clinical cure rate was15.8%, markedly effective rate57.9%, the total efficiency of73.7%. The two groups have no significant difference. The Baofukang suppository groupand clotrimazo-lesuppositories group mycological clearance rate was95%,85%, two sets of mycological clearance rate was no significant difference.3. The two treatment methods could significantly improve the RVVC patients with clinical syndromes, signs, before and after treatment, Syndrome.signs integral has significant differences (P<0.05). After treatment showed no significant difference between the two treatment methods for the improvement of the clinical efficacy and mycological efficacy between the two groups (P>0.05).4. Withdrawal the7th day and the1,2,3,5,6menstrual cycle follow-up. The group in Baofukang suppository recurrence in four cases, clotrimazole suppositories group of nine cases of recurrence, the two groups in recurrence rates were21.1%,47.3%, a significant difference in the two sets of recurrence rate, P <0.05%.Conclusion:RVVC patients with vaginal immune disorder, this may be an important pathogenesis of Candida vaginal disease recurrence. Better clinical efficacy has Baofukang suppository with fluconazole for recurrent Candida vaginosis,for RVVC patients of hot and humid place bets on TCM Syndrome, maintenance treatment of Baofukang suppository local regulation of the environment within the vagina, Can not only play the role of consolidation therapy, and can reduce the recurrence rate of RVVC.