Serum And Sputum Levels Of IL-33, ST2in Severe Chronic Obstructive Pulmonary Disease And Their Significance

Objective:To investigate serum and sputum levels of IL-33and ST2in severe Chronic Obstructive Pulmonary Disease (COPD) and their clinical significance.Methods:30patients with severe COPD (case group) and30healthy adults (controls) were recruited in this study. The serum and sputum IL-33,ST2levels were measured by ELISA in30severe COPD with acute exacerbation and remission stage,30healthy age-matched subjects.Results:The serum levels of ST2in severe COPD with acute exacerbation were significantly higher than those in normal controls (P<0.05) but the serum levels of IL-33and the sputum levels of IL-33and ST2had no significance (P>0.05). There were no statistical differences in the serum and sputum levels of IL-33and ST2between severe COPD with remission stage and normal controls. The serum levels of ST2, hs-CRP and IC%in severe COPD with acute exacerbation were remarkably higher than those in severe COPD with remission stage (P<0.05). There was no correlation among them (P>0.05).Conclusion:Serum levels of ST2might be used as a marker to evaluate the condition of acute exacerbation in severe COPD.