Influence Of Metabolic Syndrome On The Lesion Of Coronary Artery In Hypertension Patients

Objective: This study investigated the influence of metabolic syndrome（MS）on thelesion of coronary artery in hypertension patients，which may provide theoretical basis forprevention and treatment of coronary heart disease and obtain the reduction of coronaryheart disease（CHD）morbidity and mortality.Methods: A total of one hundred and seventy-seven subjects who had undergonehypertension receiving coronary angiography（CAG）because of being possiblely diagnosed ascoronary heart disease and having full information in the first hospital of Shanxi MedicalUniversity were enrolled. According to CDS MS definition the patients were divided into MSgroup79 cases and non- MS group 98 cases. The severity of coronary atherosclerosis wasestimated by CHD Gensini cumulative index and the range and distribution of the lesion ofcoronary artery which were compared in the same time. Through the comparison，the correlatedanalysis were made between metabolic syndrome and the lesion of coronary artery inhypertension patientsResults:1. The comparison of the clinical data between the two groups: The body mass index（BMI）, fasting plasma glucose（FPG）and low density lipoprotein Cholesterol（LDL-C）of MS group were significantly higher than non- MS group, whereas the high densitylipoprotein Cholesterol（HDL-C）was lower than the latter.2. The correlated analysis of metabolic syndrome and coronary heart disease: Multipleregression analysis displayed that the prevalence of CHD in MS group was significantlyhigher as compared to the groups not suffering from MS（P <0.01）. MS was one of the riskfactors for CHD（b＝1.220，OR＝3.389，95％CI 1.077－10.662，P＝0.037，P＜0.05）3. The comparison of Gensini score and the comparison of the range of the lesion ofcoronary artery : The Gensini score of MS group（42.89±26.58）was significantly higher thanthat of non-MS group which was 30.82±20.72. The MS group was mainly composed ofdouble-vessel disease and multivessel disease, whereas non-MS group was mainly composed ofSingle-vessel disease and double-vessel disease .The MS group showed a higher prevalence ofmultivessel disease and diffuse lesions than the simple hypertension group, but Single vesseldisease was less than the latter. 4. The distribution of the lesion of coronary artery: Among all of the coronary arteries, theleft anterior descending was the vessel most frequently involved in MS group, followed by leftcircumflex，right coronary artery and left main，but followed by right coronary artery，leftcircumflex and left main in non-MS group.Conclusion:1. There is significantly positive correlation between metabolic syndrome and coronaryangiography Gensini score. MS was one of the risk factors for CHD.2. Compared with the simple hypertension group, the severity of coronary lesions isincreased and complexed in the hypertension patients with MS.