Clinical Features Analysis On Patients With Both Coronary Heart Disease And Metabolic Syndrome

Objective:The aim of this study is to analyze the clinical manifestations of the patients who have both coronary heart disease(CHD)and metabolic syndrome(MS),investigate the relationship between MS and the severity of the coronary artery lesion,evaluate the predictive value of MS and its components for CHD,discuss the prevention and treatment of CHD from the way of MS.Method:1.Objects and group:We have choosen the patients with the complains of angina pectoris or myocardial infarction(MI)or chest pain from 2015.04 to 2015.10 in the People's Hospital of Liaoning Province with complete medical records.206 cases of those were confirmed as CHD by coronary artery angiography(CAG).The age ranged from 36 to 95 years old,with an average 62.5 years old,including 146 males,60 females.According to the Chinese Diabetes Society(CDS,2004)published the diagnostic criteria of MS,all patients were divided into both CHD and MS group(MS group).CHD without MS group(non-MS group).In total,116 cases were included in the MS group,87 males,29 females;90 cases for non-MS group,49 males,41 females.Meanwhile,according to the combined numbers of components of MS,we recorded the MS score of each patients,0 to 4,and then divided into group 0 to 4,21 cases for 0 group.24 cases for 1 group.43 cases for 2 group.78 cases for 3 group?40 cases for 4 group.2.Medical records collection:We have recorded the age?sex?smoking history?drinking history?hypertension history?DM history?heigh t(m)?weight(kg)?calculated body mass index(BMI)(kg/m2)for eligible patients;the laboratory report of blood serum serum total cholesterol(TC)?triglyceride(TG)?high density lipoprotein cholesterol(HDL-C)?low density lipoprotein cholesterol(LDL-C)?fasting blood-glucose(FBG)?blood uric acid(UA)?NT-proBNP collected from the elbow vein blood collected with fasting;recorded the left ventricular rejection fraction(LVEF);recorded the degree of coronary artery stenosis and the number of coronary artery lesions according to the CAG operation note for eligible patients.According to the CAG operation note,we selected the main vessel segment:left main coronary artery(LMCA)?left anterior descending branch(LAD)?left circumflex artery(LCX)?right coronary artery(RCA),the lesion blood vessel vascular damage rating according to the narrowest place.The degree of coronary stenosis according to the American heart association(AHA)was divided into 6 level rate:0 points:0-25%stenosis;1 points:26-49%stenosis;2 points:50-74%stenosis;3 points:75-89%stenosis;4 points:90-98%stenosis;5 points:99-100%stenosis.Calculated the of the major lesion blood vessels,and the sum of them was coronary artery score.3.Statistical method:The experimental data was analyzed by SPSS 17.0 statistical software.The datas were showed in the meanestandard deviation(Xde),comparison of mean between two groups was done by t test,comparison between groups X2 test.A value of P<0.05 was interpreted to denote statistical significance.Result:1.The number of patients in MS group were more than non-MS group,MS group was higher correlation with smoking than non-MS group(P<0.01);2.The FBG?TC?TG?LDL-C?UA values in MS group were higher than non-MS group,HDL-C value was lower than non-MS group(P<0.01);3.Coronary arteriongraphy score were higher in MS group than in non-MS group,Two-vessels lesions?three-vessels lesions were more in MS group than in non-MS group,one-vessels lesions were less in MS group than in non-MS group(P<0.01);4.Acute myocardial infarction(AMI)incidence was higher in MS group patients than non-MS groups(P<0.01);5.The NT-ProBNP in MS group was higher than non-MS group,LVEF value was lower than non-MS group(P<0.01);6.Patients with CHD combined the more MS components,the higher the coronary score(P<0.05).Conclusion:1,patients with CHD were likely to have concomitant MS,smoking was the risk factor of CHD combined with MS;2.There were mutiple metabolic abnormalities in patients with CHD combined with MS;3.Patients with CHD combined with MS had heavier coronary lesions than those without MS;4.patients with CHD combined with MS were more likely to have AMI;5.Patients with CHD combined with MS had poor cardiac function than those without MS;6.There was a positive correlation between MS components number and the severity of coronary artery lesions,MS components number could be used as a predictor to assess the severity of CHD.