Probe Into Clinical Significance Of Ki67Expression And Biology Characteristics In Breast Cancer As Well As Molecular Subtypes

Objective: To explore the relation between expression of Ki67and various clinicalpathological factors, staging, molecular typing, and prognosis of breast cancer and itsclinical significances.Methods: A total of692cases breast cancer patients who treated by the FujianProvincial Hospital from January2001to May2011were retrospectively analyzed.According to the postoperative pathologic, analysis of the relation between expressionof Ki67and various clinical pathological factors in breast carcinoma, and discuss theirclinical significances. Ki67test for breast cancer molecular points of type clinicalsignificance.Results: Low Ki-67expression （Ki-67<14%）accounted for24.4%, high Ki-67expression （Ki-67≥14%）accounted for75.6%. The proportion of invasive ductalcarcinoma and invasive lobular carcinoma in high Ki-67expression group more thanlow ki67expression group exists statistically significant difference (P <0.05). Ki-67expression and tumor size, lymph node status, clinical stage was positively correlated(r>0, P <0.01), while no significant relationship with age, menopausal status (P>0.01);Ki-67and Her-2expression was positively correlated (r=0.223, P <0.01), and ERexpression was negatively correlated (r=-0.105, P <0.01)，and PR expression wasnegatively correlated (r=-0.124, P <0.01). Axillary lymph node metastasis rate was31.4%, primary tumor>2cm accounted for52.9%, of the TNM staging Phase IIaccounted for64.7%in Luminal A breast cancer less than Luminal B HER-2negativebreast cancer which axillary lymph node metastasis rate was48.1%, primary tumor>2cm accounted for66.1%, more than the TNM staging Phase II accounted for78.5%exists statistically significant difference (P <0.05). Axillary lymph node metastasis ratewas39.8%, primary tumor>2cm accounted for61.9%,more than the TNM stagingPhase II accounted for77.3%in Luminal B HER-2positive breast cancer; compare with LB HER-2negative breast cancer without statistically significant difference (P>0.05).Conclusion: The expression rate of ki67is high in breast cancer, more common ininvasive ductal carcinoma and lobular carcinoma. The expression of ki67wassignificantly correlated with axillary lymph node metastasis, primary tumor size, andclinical stage. Ki67can be used as the evaluation of breast cancer development andprognosis of the biological indicators. ER, PR, Her-2detection can help to guideclinical diagnosis and treatment of breast cancer. Distinguish between luminal A andluminal B breast cancer exists significant difference in the clinical and pathologicalfeatures when ki67≥14%. There is a guiding significance to individualized treatmentof breast cancer.