Retrospective Analysis Of The Expression And Clinical Significance Between Ki67 And P53 In Young Breast Cancer Patients

Objective:To analyze the expression of Ki67 and p53 in young and young breast cancer,and to explore its relationship with clinicopathological features,its influencing factors,and its impact on prognosis.Methods:A retrospective analysis of 313 women with breast cancer who underwent surgical treatment and pathological diagnosis from January 2011 to December 2013 was included in the study.The age group≤40 years old was included in the younger age group,a total of 139 cases,aged>40 years old.The senior group,a total of 174 cases.Statistical analysis was performed on the clinical and pathological data of the two groups.Results:The difference in p53 was statistically significant(P<0.05).The positive rate of Ki67 in Luminal B(HER-2 negative)and histopathological(Ⅰ+Ⅱ)patients in the younger group was higher than that in the older group(P<0.05),in HER-2 overexpression and Sanyin.The positive rate of type,lymph node positive,node negative,and histopathological grade Ⅲ were not significantly different from those of the older group(P>0.05).The positive rate of Ki67 in the poor prognosis(HER-2 overexpression+triple negative)molecular typing was lower in the younger and older groups than in the prognosis(Luminal A+Luminal B)(P<0.05).The positive rate in lymph node-positive patients was higher than that in node-negative patients(P<0.05),and the positive rate in pathological histology class Ⅲ patients was higher than(Ⅰ+Ⅱ)patients(P<0.05).The positive rate of p53 in Luminal B(HER-2 negative)and HER-2 overexpressing patients in the younger group was higher than that in the older group(P<0.05).There was no significant difference between the positive rate of type Ⅲ,triple negative,lymph node positive,node negative,histopathological(Ⅰ+Ⅱ)and grade Ⅲ patients(P>0.05).The positive rate of p53 in lymph node-positive patients was higher than that in lymph node-negative patients in the younger and older groups(P<0.05),and the positive rate in the histological grade Ⅲ patients was higher than that in the(Ⅰ+Ⅱ)patients(P<0.05).The positive rate of p53 in the younger group was higher in patients with poor prognosis(HER-2 overexpression+triple negative)than in patients with good prognosis(Luminal A+Luminal B)(P<0.05).There was no statistical difference in the elderly group(P>0.05).Logistic multivariate regression analysis showed that tumor diameter,lymph node status,and histopathological grade were independent risk factors for Ki67 expression.Lymph node status and histopathological grade were independent risk factors for p53 expression.The follow-up results showed that the 5-year DFS and OS in the Ki67-positive group were lower than those in the negative group(64.45%and 78.77%for 5 years,and 45.67%and 63.37%for 5 years,respectively)(P<0.05),p53 positive.The DFS and OS in the 5-year group were lower than those in the negative group(62.31%and 77.37%for the 5-year OS and 43.61%and 61.07%for the 5-year DFS,respectively)(P<0.05).Conclusion:The positive expression rates of Ki67 and p53 in young breast cancer patients are higher than those in elderly patients.The positive rates of Ki67 and p53 in young patients with breast cancer were higher than those with better prognosis in the poor prognosis of molecular typing(HER-2 overexpression+triple negative),lymph node positive,and histopathological grade Ⅲ.Type(Luminal A+ Luminal B),node-negative,histopathological(Ⅰ+Ⅱ)grade patients.Independent risk factors leading to Ki67-positive expression include tumor diameter,lymph node status,and histopathological grade,and independent risk factors for positive expression of p53 include lymph node status,histopathological grade.Patients with positive expression of Ki67 and p53 have a lower 5-year OS and DFS lower than those with negative expression of Ki67 and p53.For such patients,more aggressive treatment should be taken in the clinic.