Investigation Of Antihypertensive Drug Utilization In A Second-level Of First-class Hospital In Tanggu Area Of Tianjin

Objectives:Through investigation of antihypertensive drug utilization in a second-level of first-class hospital in Tanggu area of Tianjin, learn the prescription of out-patients'antihypertensive drug rationality analysis. To study the drug use and influ-ence factors of compliance for hypertensive patients, in order to further develop our Public health and disease control policy.Methods:To investigate out-patients'antihypertensive prescriptions from January to July in 2010 used in the treatment of high blood pressure in one hospital,using amount ranking and medication use frequency ranking, the statistical analysis of the Excel oral antihypertensive medication sales amount of application varieties, and use frequency (DDDs), daily expenses (DDDc) and the joint application of the drug, etc.And then,328 hypertension patients of the out-patient were sampled by random cluster sample, a questionnaire survey was practiced including demography character, the status of drug therapy, and CPAT by face-to-face interview and family follow-up.Result:1 Single ranking in the top five varieties of use frequency in the hospital is Nifedipine Controlled-release Tablets (Adalat), Irbesartan Capsules, Benazepril (Lotensin), Valsartan (Diovan), Benzene sulfonic acid amlodipine capsules (Norvasc).Single ranking in the top five varieties of drugs used in the hospital is Nifedipine Controlled-release Tablets (Adalat), Valsartan (Diovan), Benzene sulfonic acid amlodipine capsules (Norvasc), Irbesartan Capsules, Benazepril (Lotensin). Single ranking in the top five varieties of DDDc is Valsartan(Diovan), Benzene sulfonic acid amlodipine capsules(Norvasc), Nifedipine Controlled-release Tablets(Adalat), Felodipine tablets(Plendil), bisoprolol fumarate tablets(Bisoprolol), Most Drug use index>12 The highest use frequency in the hospital is calcium channel blockers(CCB), followed by angiotensin receptor blockers (ARB), angiotensin 1-converting enzyme inhibition medicine (ACEI),β-blockers (β-RB), and traditional Chinese medicine. The total amount in the hospital is calcium channel blockers(CCB), angiotensin receptor blockers (ARB), angiotensin 1-converting enzyme inhibition medicine (ACEI),β-blockers (β-RB),The highest DDDc in the hospital is angiotensin receptor blockers (ARB), calcium channel blockers(CCB), angiotensin 1-converting enzyme inhibition medicine (ACEI),β-blockers (β-RB), a-receptor blockers,and traditional Chinese medicine.3 Antihypertensive drugs types according to domestic drug and import drug. Imported drugs are DDDs and total amount of most. Antihypertensive drugs distinguish long, medium, short-acting preparations. DDDs long-acting preparations and the total amount of responsible for most.4 49.25% of all these 8652 patents in the hospital took only one class of antihypertensive drugs.41.54 percent of all these patents took the combination class of antihypertensive drugs. The rest of the patients took the combination of three or more than three classes of antihypertensive drugs.5 There have 44.82% of hypertensive patients who belong to CPAT good group (CPAT points=4).Completely non-compliance patients (CPAT points=0) accounted for 3.05%.6 CPAT single factor analysis results are shown education degree, by the per capita monthly income, medication type, drug dosage forms, complications and rule of CPAT self-test blood pressure with a statistical significance(P<0.05). Gender, age, marital, medical expenses of payment, high blood pressure, high blood pressure, classification and to the family CPAT not statistically significant (P>0.05).7 Among non-compliance,43.09% patients was thinking that they could decrease the dose or withdrawl after the BP become normal; 22.10% of patients is not necessary to medicine when absence of symptoms.16.02% patients often forget take medication. That was the main reason which affects the CPAT of patients with hypertension.8 Between good and poor CPAT groups, in limit fat and salt intake,regular exercise,body mass index and periodic medical examinations have no significant difference. But in CPAT good group, limiting alcohol rate is higher than in CPAT poor group (P<0.025),and the smoking rate is lower than in CPAT poor group (P<0.05.);The patients in CPAT poor group can pay more attention to the emotional control (P<0.01)Conclusion:Antihypertensive drugs in the hospital the application is that the preparation of the drug combination and fixed combination is relatively low, diuretic use less than normal,needs to be improvcd; The situation of CPAT was not optimistic, health education and health promotion should be strengthened.