| Depression is a group of common mental disorders. The main features of these mental disorders presents as down in spirits. With the increase of social and psychological pressure, the morbidity showed an increasing trend in resent years. In clinic, some patients have no respond to or have poor efficacy with routine antidepressants. In general, The treatment-resistant depression is that the patient is invalid to the usage of two or more different mechanism of antidepressant with sufficient course and sufficient dosage. Reatment-resistant depression has Long course. It is difficult to cure. It affects he life quality of the patients and society very much. Treatment is more difficult. For resistant depression, it has high efficacy that the treatment with traditional Chinese medicine while use of chemical medication.Objective:To study the general law of typing and TCM Patterns for treatment-resistant depression according to syndrome differentiation. Methods:Through the epidemiological investigation, by way of epidemiological investigation, We collected the symptoms, physical signs, tongue demonstrations and pulse tracings in 150 patients with treatment-resistant depression, using Frequency as research discriminant for TCM Patterns. Results:Treatment-resistant depression long course and stress long-standing adverse events, Use a variety of antidepressant drugs, Most of the drugs combined with antianxiety drugs. There are 36 species symptoms usually seen in treatment-resistant depression. The most common of them are:incessant worries and miseries, restlessness, fatigue, lose of interest, hebetude, dysorexia, drowsiness and hypokinesia and so on。According to syndrome types, TCM Patterns devided into four category as:stagnation of liver-QI with deficiency of the spleen, stagnated QI transforming into fire, asdthenic splenonephro-yang, hepatic stagnation and retention of phlegm. Conclusions Treatment-resistant depression is different in features of TCM Patterns to common depression. |
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