Cooling Blood Xiao Feng San Psoriasis Vulgaris Of The Clinical Observation

Objective:(1) Evaluate the validity and security of Liang Xue Xiao Feng San decoction in treating active psorasis vulgaris,which belongs to blood-heat pattern in Traditional Chinese Medicine(TCM);(2) To observe the prostecdtive efficacy;(3) To study the effect of psoriasis on the patients' life qualityMethods:(1) In the clinical observation,according to the rule of single blind,random andcontrast,88 patients were divided into 3 groups:theraputic (n=29)group and control(n=30) group1, control(n=29) group2. theraputic group taking proved recipe Liangxue xiao feng san; control group1 taking Fu Fang Qing Dai capsule; control group2 taking Acitretine.To evaluate the validity , prostecdtive efficacy, recurrence rate and security;(2) To observe recurrence,following up the recovery patients for one year;(3) Using DLQI to study the life quality in the patients with psoriasis before and after treatment and comparing it with psoriasis area and severity index (PASI).Results:(1) Evaluate the treatment effect by PASI scores 8 weeks later, and analyze it with the software of SPSS13.0.As a result, Liang Xue Xiao Feng San decoction is more effective than Fu Fang Qing Dai capsule; Nearly the same as Acitretine. (P<0.05).(2) Following up the recovery patient for one year, recurrence rate of theraputic group is lower than control groupl and 2 (P<0.05).(3)Both PASI and DLQI decreased with clinical improvement after treatment. There was also a significantly positive correlation of the response rate between in PASI and DLQI scores ( P < 0.01). Conclusion:(1) The Liang Xue Xiao Feng San can significantly improve the skin lesions, pruritus degrees.reduce the PASI scores and decrease recurrence rate in blood heat syndrome of psoriasis vulgaris. Its therapeutic effects are better than the Fu Fang Qing Dai capsule; Its therapeutic effects nearly the same as theraputic group,but the side effects are more severe.(2) Psoriasis has marked effect on patients life quality and DLQI score can be a new severity and therapeutic index of psoriasis.