| Objective: To analyze the relationship between the protein expressions of X-ray repair cross-complementing 1, excision repair cross complementing 1 and the effect of radiotherapy and prognosis in esophageal squamous cell carcinoma (ESCC). Methods: The protein expression of XRCC1 and ERCC1 in 59 samples of ESCC tissues and 23 adjacent tissues were examined using SP immunohistochemical staining and were analyzed according to the clinic pathologic features and follow-up data. Results: XRCC1 and ERCC1 protein were expressed in the nucleus of tumor cells in ESCC. There were no correlation between the expression of XRCC1 and ERCC1. The positive expression rate of XRCC1 protein in ESCC and adjacent tissues were 52.5% and 13.0%, respectively(P=0.001). The positive expression rate of ERCC1 protein in ESCC and adjacent tissues were 33.9%and 65.2%, respectively(P=0.010). The positive expression rate of XRCC1 protein in the group of Han nation and the group of minority were 72.2% and 43.9%, respectively (P=0.045). The positive expression rate of ERCC1 protein in the negative lymphnode group and positive lymphnode group were 48.3% and 20.0%, respectively (P=0.022). The short-term effect of radiotherapy in the negative-XRCC1 group (92.9%)was higher than that in the positive-XRCC1 group(80.6%), P=0.323. The median survival period and 95 confidence interval in the group of positive expression of ERCC1 and the group of negative expression of ERCC1 were 13.2 months, 10.1～16.3 months, 21.4 months and 19.1～23.7 months, respectively(P=0.001). In multivariate analysis, the expression of ERCC1 and the tumor length were closely correlated with over all survival and were the independent prognostic factor(sP=0.001, 0.037). Conclusion: The protein expression of XRCC1 and ERCC1 may contribute to the risk of developing ESCC. The expression of ERCC1 is closely correlated with the lymphnode metastasis and effect of radiotherapy, and its positive expression is an unfavorable factor for prognosis of ESCC. |
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