| Objective:Filler particles on the two yellow treatment of Qi and blood disorders square type Vitiligo clinical efficacy and objective evaluation of its clinical efficacy of Vitiligo, and further analysis and to explore its mechanism.Methods:1. Pairs from January 2009 to November 2009 during the First Hospital of Wuhan City,95 cases of patients with Vitiligo specialist retrospective study found 46 cases of the use of two yellow filler particles side,49 cases of the use of cured white syrup(hereinafter referred to as the treatment group and control group). The treatment group 46 cases, male 17, female 29, age 13-56 years old; the control group 49 cases, male 20 cases, female 29, age 2-54 years old. Treatment group was given two yellow filler particle side twice daily oral administration of a pair of blunt; the control group was treated with cured white syrup twice a day, each 20ml. Drilling amine groups of adenosine in patients with oral tablets, each 2 tablets three times a day; advanced Halometasone ointment are for external use, stable period are outside the rub Angelica tincture (Wuhan City, First hospital-made), or cured white tincture (Anhui Guochuang drug Co., Ltd. production) 2 times a day, 1 month for a course of treatment, continuous treatment of 3 courses2. Criteria of therapeutic effect referred to the clinical types and Criteria of therapeutic effect of Vitiligo.2003 edition was given as follows:recovery:after 5 months of the treatment, the lesion area recovers the normal skin; Remarkable effect:after 5 months of the treatment, the recovered area is accounting for at least 50% of the original area; Effect:after 5 months of the treatment, the recovered area is accounting for 10%-50% of the original area; Failure:After 5 months of the treatment, the recovered area is unchanged or not accounting for 10% of the original area.3. These two groups are in line with Vitiligo Diagnosis (diagnostic criterion-referenced assessment in June 1994 the State Chinese Medicine Administration issued a "white barge wind diagnostics based on syndrome classification, efficacy evaluation standards"), and TCM as a blood disorder type is to observe them. The two groups in gender, age, duration, etc, The difference was not statistically significant (P> 0.05), with a comparable observation period was 3 months.4. The safety of drug treatment testing and feedback, recording adverse events.5. Comparing the treatment group and control group before and after treatment of Vitiligo patients with skin rash changes in the area to carry out mathematical statistical analysis and drawing conclusions.Results:1. Return visit found that some patients in general to enhance the existing normal skin, usually around 3-4 weeks of medication, the skin white, especially after exercise exposure or white red, white border began to clear and stable spot occurring at the new hair follicle pigment spots.4-8 weeks most of the patients with advanced disease can be controlled.2. After 3 months after treatment, the treatment group cure rate, with a total effective rate compared with the control group, no significant difference between the two, the total efficiency of 76.09% and 53.06% compared the control group, P<0.05 significant difference between the two.3. Choice of tyrosinase enzyme activity and animal-induced pigment potent Medicines side effect of treatment of Vitiligo with a positive.4. two yellow filler particles compared to cured white syrup can significantly improve the treatment of vitiligo patients and with the degree of compliance, and better improve the curative effect.Conclusion:TCM treatment of Vitiligo can change the pigment spot to reduce the rash area. Two yellow filler on Treatment of Vitiligo with good safety, efficacy accurate, patients won praise, worthy to be popularized. |
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