Analysis Of Patch Test: A Study Of 68 Eczema Patients

[Objective] Study the difference in patch test of the major sensitizing allergens in patients with eczema accourding to gender, site of lesion and age.【Methods】68 cases of eczema patients were collected from Huashan Hospital dermatology clinic and then underwent patch testing. All cases were divided into groups according to the distribution of rash namely the hand eczema group and the trunk and limbs eczema group. Patch test positive rates were then determined in the groups, and according to gender and age in the different groups. Chi-square test and fisher exact test were used to determine the statistical differences among the groups. SAS 9.2 statistical software was used for analysis.【Results】Of 68 eczema patients,53 cases were patch test positive yielding a positive rate of 77.94%, among which 25 cases had hand eczema with positive rate of 86%,28 cases of trunk and limbs eczema with positive rate of 71.79%. The first 5 major allergens were Nickel Sulfate, Carba mix, Cobalt Dicholoride, Thimerosal, Potassium Dichromate. Major allergens in hand eczema were:Nickel sulfate, Potassium dichiromate, Carba mix, thimerosal, Cl+Me-isothiazolin-ketone, p-pheylenediamine. Major allergens in trunk and limbs group were:Nickel sulfate, Cobalt Chloride, Carba mix, Thimerosal, Cl+Me-isothiazolin-ketone, p-pheylenediamine The positive rate of Carba mix was significantly higher in hand eczema patients than in trunk and limbs eczema patients (P<0.05). Epoxy Resin and Mercaptobenzothiazole had higher positive rates in male patients with statistically significant difference (P<0.05). Compared with male patients positive reactions to Quaternium-15 were more frequently in the female patients. Patch test positive rates in different age groups were not statistically significant.[Conclusion] Nickel sulfate, Carba mix, cobalt chloride, thimerosal, potassium dichromate may be the most important allergens in eczema. Patch test is important in routine prevention and in ascertaining specific allergens of allergic contact dermatitis.