| Background There is close relationship between Type 2 diabetes and cardiovascular disease. The main death of type 2 diabetes mortality is cardiovascular disease. About more than one fourth of the patients with Type 2 diabeties have the metabolic syndrome.More and more Chinese patients with diabetes and obesity have the serum aminotransferase elevation which means the damage of the liver by lipids. Some arthors suggested the non-alcoholic fatty liver disease is the condition of metabolic syndrome. The elevation of aminotransferase is one of the cardiovascular risk factors. Objective To investigate the relationship between the increased alanine aminotransferase (ALT) level with the glucose, lipids disorder. Methods the patients with type 2 diabetes and finished the diabetic complication assessment had been surveyed for the metabolic disorder and BMI, waist circumference, liver function. After excluding the diabetic patients with infective and other secondary hepatopathy, all the patients were divided into two groups based on their blood alanine aminotransferase level, normal or abnormal (> 40 U/L). The body weight, glucose and lipids were compared between the two groups.Results 4509 patients were divided into Group A (n=449, with high ALT) and Group B (n=4060, normal ALT). Comparative with GB, The patients of GA were relatively younger (48.4±11.6 vs. 55.7±11.4 yrs, p< 0.05),shorter duration of diabetes (36.8±44.2 vs 58.4±60.9 months ) , higher BMI and waist /hip circumference(27.8±3.8 vs 25.7±3.4,p<0.05;0.95±0.06 vs 0.92±0.07, p<0.05 ). No difference between the systolic blood pressure but higher diastolic blood pressure (131.8±18.8/78.1±9.6 vs. 131.3±21.2/74.4±10.0 mmHg, p>0.05/<0.05),fasting glucose, 2 hours blood glucose after meal and HbA1c were significantly higher than control group(9.0±2.9 vs. 8.6±3.7, 13.9±4.7 vs.13.0±4.9 mmol/L,8.1±1.8 vs. 7.7±2.0%), fasting, post-meal blood insulin and insulin resistance index were higher (10.8±7.3 vs. 7.8±6.8,49.7±43.7 vs. 35.1±32.5 uIU/ml,4.11±2.9 vs. 2.91±2.8 ),TG increased(2.8±2.5 vs. 2.1±2.8 mmol/L),HDL-C was lower (1.2±0.2 vs. 1.3±0.8 mmol/L),urine albumin excretion was higher (Log Alb(mg)/Cr(g):1.32±0.5 vs. 1.24±0.5 ug/g,p<0.05).No significantly difference between two groups on the cholesterol, LDL-C, uric acid and creatinine.Conclusions: The patients with higher ALT were younger, and have more cardiovascular risk factors. |
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