The Effect Of Vitamin D On Cardiovascular Risk Factors With Type 2 Diabetes

Objective:This study is mainly to study the effect of Vitamin D treatment on cardiovascular risk factors in type 2 diabetes complicated high LDL-c with Viamin D deficiency.Methods:This study collected 81 cases of type 2 diabetes complicated high LDL-c with Viamin D deficiency hospitalized in First Affiliated Hospital of Hebei North University in Zhangjiakou,Hebei province in March to May in 2017,randomly divided into treatment group and the observation group,treatment group 40 cases,41 cases of observation group.Patients were given the basic treatment,concluding lifestyle intervention,control of blood pressure and blood glucose,regulating blood lipid.Treatment group and then given Viamin D3.The total course was 24 weeks.Collect patient general information,such as age,gender,diabetes duration,etc.,records the dates of two groups before treatment respectively,as follow :LDL-c、FBG,2h PBG,FINS,Hb A1 c,blood pressure,IMT and calculates HOMA-IR.After 24 weeks of treatment,both groups inspect the indicators of initial examination,and analyzed and compared the relevant indicators,to investigate whether the use of vitamin D therapy in Vitamin D deficiency in patients with type 2 diabetes has an effect on cardiovascular related factors.SPSS17.0 software is used to analyze the data of the selected indexes,and the difference of P<0.05 is significant.Statistical methods adopted: t test,chi-square test.Result: Compared to pre-treatment,LDL-c,FBG,2h PBG,Hb A1 c,and blood pressure decreased in the two groups after treatment,with statistically significant differences(P < 0.05).And the treatment group after treatment of LDL-c,FBG,blood pressure is lower than the observation group,the difference was statistically significant(P<0.05),while the treatment group after treatment of 2h PBG、Hb A1 c compared with observation group after treatment of 2h PBG 、 Hb A1 c,there was no statistically significant difference(P>0.05).The two groups before and after the treatment of IMT 、 HOMA-IR comparison,there was no statistically significant difference(P >0.05).Conclusion: the CRF of T2 DM patients can be declined by comprehensive treatment such as control of blood pressure and regulating blood lipid and blood glucose.For T2 DM patients with high LDL-c combined with Viamin D deficiency,given reasonable complement Vitamin D could reduce CRF further.It is suggested that the combined application of Vitamin D in the treatment of T2 DM with high LDL-c may be of some significance.