| BackgroundPatients with acute liver failure or gastrointestinal dysfunction, gastrointestinal failure in clinical presentation, treatment and prognosis of severely affected, current clinical application of medicine are not effective. Traditional Chinese medicine has always paid attention and motor function of gastrointestinal digestion and nutrient absorption in the relationship between the emphasis on both yin and yang with mercy, interacts in the adjustment of gastrointestinal function has accumulated rich clinical experience and side effects, More and more attention. This observation of traditional Chinese medicine preparation Zhishi Xiaopi Tang (Li Dongyuan) high, medium and low dose group and the mosapride group of rats with acute liver failure gastrointestinal interdigestive migrating motor complex (migrating motor complex, MMC) change Effects, thereby to explore the Zhishi Xiaopi Tang on rats with acute liver failure treatment of gastrointestinal dysfunction, simultaneous detection of acute liver failure in the normal group and the serum motilin (MTL), leptin (Leptin) and Hunger hormone (Ghrelin) concentration in acute liver failure in this study the concentration changes of gastrointestinal hormone, which in acute liver failure mechanism of gastrointestinal dysfunction.MethodsBy D-galactosamine liver failure caused by rats, with multi-channel physiological recorder records the normal control group, respectively, and acute liver failure model, the positive control group mosapride and Zhishi Xiaopi soup high, medium and low Dose group the duodenum MMC gastrointestinal interdigestive migrating motor complex, MMC and the rats of the indicators for comparative analysis, using enzyme-linked immunosorbent assay (ELISA) detection of normal and acute liver failure in the motilin serum Leptin and ghrelin concentrations, the concentration difference between the two groups were compared.ResultsWith the normal control group compared to rats with acute liver failure group, the duodenum MMCâ…¡phase lasted significantly longer, the difference was statistically significant (p = 0.001); compared with normal control rats Comparison group of acute liver failure in rats gastric duodenum, MMCâ…¢phase duration was significantly shorter (p = 0.001).Compared with the mosapride group, Zhishi Xiaopi soup high dose group and dose group in the duodenum MMCâ…¡phase difference was not statistically significant (p = 0.658, p = 0.879); and low dose Dose group compared to the duodenum MMCâ…¡was significantly reduced compared (p = 0.001); and mosapride group compared Zhishi Xiaopi soup high dose group and dose group in the Duodenum, the duration of MMCâ…¢phase difference was not statistically significant (p = 0.567 and 0.441, respectively), Zhishi Xiaopi soup in the high dose group and dose group compared to the duodenum the duration of MMCâ…¢phase difference was not statistically significant (p = 0.841); compared with the low dose group and high dose group and in the Dose of duodenum MMCâ…¢phase lasted significantly longer, the differences were statistically significant (p = 0.006, p = 0.004); and mosapride group compared Zhishi Xiaopi soup high , The low dose group was not statistically significant change in cycle (p = 0.372,0.347,0.716).Acute liver failure rats compared with control rats ghrelin concentrations were significantly increased, the difference was statistically significant (t value was -4.531 and -7.210 p <0.05); acute liver failure rats compared with normal control group The motilin concentration was significantly higher, the difference was statistically significant (t value was -2.064 and -2.530 p <0.05); acute liver failure rats compared with control rats leptin concentrations were significantly increased, and the difference Significant difference (t value was -3.550 and -6.031 p <0.05). ConclusionAcute liver failure in rats the duodenum MMCâ…¡phase was significantly prolonged contraction was transitional cluster, MMCâ…¢was significantly reduced relative to the above may lead to acute liver failure rat gastrointestinal motility disorder appears bloating, nausea, vomiting, anorexia and so the main reason. Zhishi Xiaopi soup high, medium and low-dose group and both mosapride group of rats with acute liver failure and shortened MMCâ…¡phase extension of MMCâ…¢significant improvement relative to the role, in which high doses of Zhishi Xiaopi soup and Hermosa Billy better low dose group. Acute liver failure patients for the clinical gastrointestinal motility disorder that appears to provide an effective treatment. Acute liver failure motilin, leptin, ghrelin concentrations were significantly higher than the concentration of the control group, which may be increased gastrointestinal hormone gastrointestinal dysfunction, liver appears nausea, vomiting, tired of oil, abdominal distension Symptoms such as one of the reasons for the further study of acute liver failure mechanism of gastrointestinal dysfunction in patients with clinical evidence available. |
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