Regulatory Mechanism Of Interdigestive Gastrointestinal Migrating Motor Complex And Its Clinical Significance

Migrating motor complex (MMC) mainly exists in the interdigestive period. Its regulatory mechanisms are not clear. Electrogastrogram(EGG) is an useful and noninvasive tool for diagnosing the gastric motility disorders, which has been developing rapidly due to application of computer, but it has not been well known whether EGG can reflect MMC and gastric emptying. The effects of many factors lespecially brain-gut peptides in enteric nervous system (ENS)] on MMC in the dogs, regulatory role of MMC in human beings, and relationship between EGG and MMC (?)(?) between EGG and gastric emptying were investigated in the studyMMC was recorded by strain gauge transducers implanted on the serosa of gut in conscious dogs. Three silastic catheters for injecting drugs and taking blood snmplcs were inserted into a vena jugularis externa , arteria pancreaticoduodenalis superior perfusing proximal duodenum and a jejuna) artery which perfused a 10-15 cm intestinal segment.The present study was undertaken to observe the effect of chugs administered intravenously and intraarterially on MMC and alterations of plasma 5-hydroxytryptamine(5-HT) and motilin in different phases of MMC. EGG and gastric pressure or gastric emptying were performed simultaneously in healthy subjects, patients with functional dyspepsia(FD) or with diabetic gastroparesis (DGP) Blood samples were taken in different phases of MMC for evaluating the role of plasma motilin on the initiation of MMCThe results showed that: (1) Levels of plasma 5-HT and motilin showed cyclical Huctuations in different phases of MMC, and 5-HT reached peak before peak of motilin. 5-HT₄ receptor antagonist abolished the increase in plasma motilin concentration. These suggest 5-HT stimulates the release of motilin. (2) L-NAME, (?)(?) inhibitor of nitric oxide synthase , administered intravenously and intraarterially during phase I at duodenum, could initiate continuous contractions in stomach and duodenum. After intravenous L-arginine, the duration of phase I of MMC in stomach and duodenum was longer than that without L-arginine, and motility indexes during phase II and during phase III in stomach and duodenum significantly...