Effect Of Rhubarb On Gastrointestinal Mucosal Barrier In Patients With Severe Burns

Objective:To observe the effect of rhubarb on gastrointestinal mucosal barrier in patients with severe burns at early stage.Methods:Thirty patients with severe burns were randomly divided into therapeutic group (T) and control group (C, not use rhubarb). The blood samples were harvested at 3,7,14 post burn days (PBD) to determine the levels of MTL, GAS, DAO and ET.Results:The levels of serum GAS and MTL in T group were significantly higher than those in C group at 3,7,14 PBD, respectively(P<0.05). The levels of serum ET in T group were significantly lower than those in C group at.3,7,14 PBD, respectively(P<0.05). The levels of serum DAO in T group were significantly lower than those in C group at 3,7 PBD, respectively(P<0.05). The levels of serum DAO in T group were lower than those in C group at 14 PBD, but there was not statistical difference.Conclusions:Rhubarb can increase secretion of gastriointestinal hormones in patients with severe burns and reduce the intestinal mucosa permeability. Rhubarb can preserve the intestinal mucosal barrier in patients with severe burns.