The Clinical Observation On The Therapeutic Effect Of Application Zhongji Point With Removing Retained Water Plaster Therapy For Malignant Ascites

Research background:Malignant ascites is a clinical symptoms which is difficult to control and patients suffer from. It indicates the emergence of the end-stage of tumors. The current treatment to malignant ascites is still to reduce symptoms and to improve the quality of life and to prolong the survive period accordingly. Now the western treatment are not many, and each has drawbacks, so we lack a effective method in clinical. Most of western medicine can bring obvious side effects and the recurrence of ascites symptoms easily, or even lead to a vicious circle which affect the survival rate directly. Malignant ascites can be attributed to "tympanites" in scope in traditional Chinese medicine.We have accumulated rich experience for the medical treatment to malignant ascites with traditional Chinese medicine, especially drug for external use is effective, safe and reliable which were reported in clinical. Because there is not a exact and effective therapy for malignant ascites in western medicine, Zhongji points application therapy with removing retained water plaster is a worthwhile attempt means in the treatment of malignant ascites suffer base on the efficacy and safty of Chinese herbs application therapy and the operability in clinical.The results can give reference for further evaluation on clinical effective of malignant ascites.Research purpose"Review on the efficacy and safety of removing retained water plaster. To pioneer a new therapy for maglignant ascites with TCM. To accumulate experience for deeper research. To provide foundation medical data for exploiting and applying removing retained water plaster. To explore a better method for improving the life quality of patients suffering from malignant ascites and prolonging the the survive period.Research methods:By using randomized single-blind prospective control study, we establish the sample dignostic criteria, include into criteria, eliminate criteria and terminate clinical test criteria.60 patients with malignant ascites were divided into treatment group (n=30) and control group (n = 30)randomly. The treatment group was treated with intraperitoneal injection with cisplatin 60mg and dexamethasone 5mg(once a week) after extracting certain maglinant(1000-2000ml)by abdominal puncture,then was treated by 4-6 hours continuous applying with removing retained water plaster in Zhongji points once-daily for three weeks. The control group was treated with intraperitoneal injection of cisplatin 60mg and dexamethasone 5mg(Once a week) after extracting certain ascites(1000-2000ml) by abdominal puncture once a week for there times totally. The change of ascites, the improvement of symtoms and the adverse reaction was observed, then the data was analyzed statistically.Resarch Results:The results showed that the effective rate of the treatment group and the control group were 83.3% and 60% respectively. The chi-square test demonstrated that there was statistifical significance between them(P<0.05), which showed the therapeutic effect of the treatment group was superior to that of the control group. The index such as intergroup decrement of abdominal circumference, the 24 hours urine increasing volume, Karnofsky score and physical state grade etal were significant difference (P<0.05) after treatment. The symptoms improvement and the adverse reaction in the treatment were better than those in the control group. The defference of the blood routine examination, liver and kidney function between the two groups were not significant or those in treatment group were better than those in control group obviously.The treatment group had advantages in reliability and safety comparing to the control group.Research conclusion:Application Zhongji point with removing retained water plaster is a effective mean to control spleen-kidney yang deficiency malignant ascites. The therapeutic effect obviously increased, the life quality was improved while the toxic and side effects decreased to certain degree through combining the western conventional therapy to application Zhongji point with removing retained water plaster which can be regard as one of measures to treatment malignant ascites in clinical practice. The treatment of application point with removing retained water plster is simple, conveninent and has better operability, safty and reliability, which is worth to extend application.