Expressions Of PAF On The Protecting Effect Of JZYYP On The Gastric Mucosa Of Rats And Its Mechanism For This Effect

Objective to observe expression of PAF in protecting effect of JZYYP to acetic acid-induced actu gastric mucosa of rats,and analyze the mechanism for this effect.Methods①Fifty SD wistar rats were randomly assigned into 5 groups,they were JZYYP high-dos group(HD group),JXYYP low-dos group(LD group),SMD group, NS group,Empty group.The 44.76g/(kg·d) and 14.92g/(kg·d) of JZYYP suspl were pre-given oral reapectively to the Chinese drug groups;the 3.0g/(kg·d) of SMD was given to the western drug group;The other two groups were fed with Sodium Chrilode.The animal models were established with improved Okabe methods in a week,but the empty group were sham operated by Sodium Chrilode, instead of acetic acid.②Then half of rats in each group were killed,and the gastric mucosa was observed by naked eyes for the damage exponent.③The SABC method of immunocytochemistry was used to show the expressions of PAF in the gastric ulcer tissue.Results The experiments showed that,7 hours after the models were made, the damage exponent of the HD group and LD group were significantly diferent(P＜0.05) from the NS group and Empty group,but the disparity of the exponents between NS group and Empty group was(P＞0.05) not marked. after 7 days,the damage exponent of the drug-given groups were signifi-cantly diferent(P＜0.05) from the NS group,and the therapeutic efficacy of the JZYYP on mucosa damage were significantly diferent(P＜0.05) from the SMD group, but the disparity of the exponents between HD group and LD group was(P＞0.05) not marked.The expression of PAF in the gastric ulcer tissue among the groups were nonsence to statistical analyze. Conclusoin JZYYP suspl could depress the damage exponent of acetic acid -induced actu gastric mucosa of rats.It indicated that JZYYP could prevent and heal the gastric ulcer,and the therapeutic efficacy was not depend on the dosage of drugs.JXYYP could accelerate the healing of the gastric ulcer.The expression of PAF in the gastric ulcer tissue among the groups indicated that the dosage of PAF in protecting effect of JZYYP to acetic acid -induced actu gastric mucosa of rats was invariant.